| Gene Symbol |
ADGRB1
|
| Entrez Gene |
575
|
| Alt Symbol |
BAI1, GDAIF
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
adhesion G protein-coupled receptor B1
|
| Other Description |
brain-specific angiogenesis inhibitor 1
|
| Swissprots |
O14514
|
| Accessions |
EAW82323 O14514 AB005297 BAA23647 AK123982 BC156200 AAI56201 XM_011517199 XP_011515501 XM_011517200 XP_011515502 XM_011517201 XP_011515503 XM_011517202 XP_011515504 XR_928342 NM_001702 NP_001693
|
| Function |
Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. May function in cell adhesion and signal transduction in the brain. {ECO:0000269|PubMed:11875720}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:12074842}; Multi-pass membrane protein {ECO:0000269|PubMed:12074842}. Note=Likely to be concentrated at cell-cell adhesion sites.
|
| Tissue Specificity |
Specifically expressed in brain. Reduced or no expression is observed in some glioblastoma cell lines and cancer tissues. No expression in astrocytes. {ECO:0000269|PubMed:11875720, ECO:0000269|PubMed:12074842, ECO:0000269|PubMed:12507886}.
|
| Top Pathways |
p53 signaling pathway
|
![Western Blot: BAI1 Overexpression Lysate (Adult Normal) [NBP2-08183] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for BAI1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10233_BAI1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-08183-img0001.jpg)