| Gene Symbol | IKBKG |
|---|---|
| Entrez Gene | 8517 |
| Alt Symbol | AMCBX1, FIP-3, FIP3, Fip3p, IKK-gamma, IMD33, IP, IP1, IP2, IPD2, NEMO, ZC2HC9 |
| Species | Human |
| Gene Type | protein-coding |
| Description | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma |
| Other Description | I-kappa-B kinase subunit gamma|IKKAP1|IKKG|IkB kinase gamma subunit|NF-kappa-B essential modifier|NF-kappa-B essential modulator|NFkappaB essential modulator|ikB kinase subunit gamma|ikB kinase-associated protein 1|incontinentia pigmenti|inhibitor of nuclear factor kappa-B kinase subunit gamma |
| Swissprots | Q7Z7F1 Q7LBY6 Q9Y6K9 |
| Accessions | AAL27012 CAB93146 EAW72677 EAW72678 EAW72679 EAW72680 EAW72681 Q9Y6K9 AF062089 AAD12183 AF074382 AAC36330 AF091453 AAD38081 AF261086 AAF99679 AK000593 AK308366 AY114157 AAM44073 AY429546 AY429547 AY429548 BC000299 AAH00299 BC012114 AAH12114 BC046922 AAH46922 BC050612 AAH50612 BT019621 AAV38427 DC410130 DQ891383 ABM82309 DQ894560 ABM85486 XM_005274760 XP_005274817 XM_005274761 XP_005274818 XM_005274764 XP_005274821 XM_011531203 XP_011529505 XM_011531204 XP_011529506 XM_011531205 XP_011529507 XM_011531206 XP_011529508 XM_011531207 XP_011529509 NM_001099856 NP_001093326 NM_001099857 NP_001093327 NM_001145255 NP_001138727 NM_003639 NP_003630 |
| Function | Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'- linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B- mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination. {ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20724660}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:14651848}. Nucleus {ECO:0000269|PubMed:14651848}. Note=Sumoylated NEMO accumulates in the nucleus in response to genotoxic stress. |
| Tissue Specificity | Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Top Pathways | Herpes simplex infection, Viral carcinogenesis, PI3K-Akt signaling pathway, HTLV-I infection, Epstein-Barr virus infection |