IKBKG

Gene Symbol	IKBKG
Entrez Gene	8517
Alt Symbol	AMCBX1, FIP-3, FIP3, Fip3p, IKK-gamma, IMD33, IP, IP1, IP2, IPD2, NEMO, ZC2HC9
Species	Human
Gene Type	protein-coding
Description	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
Other Description	I-kappa-B kinase subunit gamma|IKKAP1|IKKG|IkB kinase gamma subunit|NF-kappa-B essential modifier|NF-kappa-B essential modulator|NFkappaB essential modulator|ikB kinase subunit gamma|ikB kinase-associated protein 1|incontinentia pigmenti|inhibitor of nuclear factor kappa-B kinase subunit gamma
Swissprots	Q7Z7F1 Q7LBY6 Q9Y6K9
Accessions	AAL27012 CAB93146 EAW72677 EAW72678 EAW72679 EAW72680 EAW72681 Q9Y6K9 AF062089 AAD12183 AF074382 AAC36330 AF091453 AAD38081 AF261086 AAF99679 AK000593 AK308366 AY114157 AAM44073 AY429546 AY429547 AY429548 BC000299 AAH00299 BC012114 AAH12114 BC046922 AAH46922 BC050612 AAH50612 BT019621 AAV38427 DC410130 DQ891383 ABM82309 DQ894560 ABM85486 XM_005274760 XP_005274817 XM_005274761 XP_005274818 XM_005274764 XP_005274821 XM_011531203 XP_011529505 XM_011531204 XP_011529506 XM_011531205 XP_011529507 XM_011531206 XP_011529508 XM_011531207 XP_011529509 NM_001099856 NP_001093326 NM_001099857 NP_001093327 NM_001145255 NP_001138727 NM_003639 NP_003630
Function	Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'- linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B- mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination. {ECO:0000269|PubMed:14695475, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20724660}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:14651848}. Nucleus {ECO:0000269|PubMed:14651848}. Note=Sumoylated NEMO accumulates in the nucleus in response to genotoxic stress.
Tissue Specificity	Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Top Pathways	Herpes simplex infection, Viral carcinogenesis, PI3K-Akt signaling pathway, HTLV-I infection, Epstein-Barr virus infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FIP3 protein fragment - ab160628 from Abcam Category Protein Source Wheat germ Species Human

Human IKK gamma full length protein - ab125589 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human IKK gamma full length protein - ab160070 from Abcam Category Protein Source Wheat germ Species Human

Human IKK gamma protein fragment - ab160071 from Abcam Category Protein Source Wheat germ Species Human

IKK gamma peptide - ab7896 from Abcam Category Peptide

IKBKG / NEMO / IKK Gamma Antibody Blocking Peptide - LS-E5689 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IKBKG / NEMO / IKK Gamma Antibody Blocking Peptide - LS-E29947 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

IKBKG / NEMO / IKK Gamma Antibody Blocking Peptide - LS-E10444 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IKBKG / NEMO / IKK Gamma Antibody Blocking Peptide - LS-E10443 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IKK gamma Recombinant Protein - H00008517-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

IKK gamma Partial Recombinant Protein - H00008517-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

IKK gamma Peptide - NBP1-76799PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

IKK gamma Peptide - P1336 from Novus Biologicals Category Peptide Species Human

IKK gamma Peptide - P1334 from Novus Biologicals Category Peptide Species Human

IKBKG-Antibody-N-term-Blocking-Peptide - BP18224a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Phospho-IKKgS43-Antibody-Blocking-peptide - BP3130a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Phospho-IKKgS31-Antibody-Blocking-peptide - BP3128a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

IKK gamma peptide - GTX27896 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

IKBKG peptide - orb218152 from Biorbyt Category Peptide Prices $357.00, $723.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

NEMO / IKBKG - H00008517-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

NEMO / IKBKG - H00008517-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

NEMO / IKBKG - H00008517-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

NEMO / IKBKG - H00008517-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

IKK gamma Peptide - 2335P from ProSci Category Peptide Species Human

IKBKG fusion protein - Ag13358 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

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