| Gene Symbol |
PPP2CB
|
| Entrez Gene |
5516
|
| Alt Symbol |
PP2Abeta, PP2CB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein phosphatase 2, catalytic subunit, beta isozyme
|
| Other Description |
PP2A-beta|protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform|protein phosphatase 2, catalytic subunit, beta isoform|protein phosphatase 2A catalytic subunit, beta isoform|protein phosphatase type 2A catalytic subunit|serine/threonine protein phosphatase 2A, catalytic subunit, beta isoform|serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
|
| Swissprots |
Q6FHK5 P11082 D3DSV4 P62714
|
| Accessions |
AAA36467 EAW63433 EAW63434 EAW63435 EAW63436 P62714 AF444006 AAL35904 AK091875 BAG52434 BC012022 AAH12022 BG716837 BT019526 AAV38333 CA419001 CF594136 CR541747 CAG46547 J03805 AAB38020 X12656 CAA31183 NM_001009552 NP_001009552 NM_004156
|
| Function |
PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. {ECO:0000269|PubMed:2555176}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:16541025}. Nucleus {ECO:0000269|PubMed:16541025}. Chromosome, centromere {ECO:0000269|PubMed:16541025}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:16541025}. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles.
|
| Top Pathways |
Sphingolipid signaling pathway, Adrenergic signaling in cardiomyocytes, AMPK signaling pathway, Hippo signaling pathway, TGF-beta signaling pathway
|