TMEM67

Gene Symbol TMEM67
Entrez Gene 91147
Alt Symbol JBTS6, MECKELIN, MKS3, NPHP11, TNEM67
Species Human
Gene Type protein-coding
Description transmembrane protein 67
Other Description Meckelin|meckel syndrome type 3 protein
Swissprots G5E9H2 B3KRU5 Q3ZCX3 Q8IZ06 Q5HYA8 Q7Z5T8 B3KT47
Accessions EAW91701 EAW91702 EAW91703 Q5HYA8 AK026742 AK092244 BAG52507 AK094935 BAG52959 AK297676 BAG60037 AK308071 AK308735 BC017974 BC031220 BC032835 AAH32835 BC054338 BM310097 BX648768 CAI45999 DA928293 DC368894 JF432845 ADZ16062 XM_006716686 XP_006716749 XM_006716687 XP_006716750 XM_011517363 XP_011515665 XR_428387 XR_928360 XR_928361 XR_928362 NM_001142301 NP_001135773 NM_153704 NP_714915 NR_024522
Function Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in centrosome migration to the apical cell surface during early ciliogenesis. Involved in the regulation of cilia length and appropriate number through the control of centrosome duplication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC). {ECO:0000250, ECO:0000269|PubMed:17185389, ECO:0000269|PubMed:19515853, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:19815549}.
Subcellular Location Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. {ECO:0000250}.
Tissue Specificity Widely expressed in adult and fetal tissues. Expressed at higher level in spinal cord. {ECO:0000269|PubMed:16415887, ECO:0000269|PubMed:17185389}.

MKS3 CRISPR/Cas9 KO Plasmid (h) - sc-410508 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MKS3 HDR Plasmid (h) - sc-410508-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MKS3 Double Nickase Plasmid (h) - sc-410508-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MKS3 Double Nickase Plasmid (h2) - sc-410508-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MKS3 CRISPR Activation Plasmid (h) - sc-410508-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MKS3 CRISPR Activation Plasmid (h2) - sc-410508-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MKS3 Lentiviral Activation Particles (h) - sc-410508-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MKS3 Lentiviral Activation Particles (h2) - sc-410508-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MKS3 siRNA (h) - sc-77580 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MKS3 shRNA Plasmid (h) - sc-77580-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MKS3 shRNA (h) Lentiviral Particles - sc-77580-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU086651 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21659 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21659 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03942 from Sigma-Aldrich

Category miRNA

TMEM67 siRNA (Human) - CRJ4015 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TMEM67 - MBS8238247 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TMEM67 (NM_153704.5) - SHH430876 from Creative biogene

Category siRNA
Species Reactivities Human

Human TMEM67 siRNA - orb274516 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TMEM67 shRNA Plasmid (Human) - CHJ4015 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TMEM67 miRNA 3'UTR clone - MiUTR3H-10872 from Creative biogene

Species Reactivities Human

TMEM67 miRNA 3'UTR clone - MiUTR3H-10873 from Creative biogene

Species Reactivities Human
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