| Gene Symbol |
HTR3A
|
| Entrez Gene |
3359
|
| Alt Symbol |
5-HT-3, 5-HT3A, 5-HT3R, 5HT3R, HTR3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
|
| Other Description |
5-HT3-A|5-hydroxytryptamine receptor 3|5-hydroxytryptamine receptor 3A|5HT3 serotonin receptor|serotonin receptor 3A|serotonin-gated ion channel receptor
|
| Swissprots |
G5E986 Q9BSZ9 Q7KZM7 B4DSY6 P46098 Q99918 O60854
|
| Accessions |
AAB71736 ACE96268 ACE96273 ACE96283 ACE96288 ACE96293 ACE96298 ACE96303 ACE96308 CAA06442 EAW67237 EAW67238 EAW67239 EAW67240 P46098 AF498984 AAM21131 AJ003078 CAA05851 AJ003079 CAA05852 AJ003080 CAA05853 AK299973 BAG61798 AK304630 BAG65410 AK313896 BAG36619 BC002354 AAH02354 BC004453 AAH04453 BT007204 AAP35868 BT008266 AAP36958 CD014118 D49394 BAA08387 DQ892003 ABM82929 DQ895193 ABM86119 S82612 AAB37533 NM_000869 NP_000860 NM_001161772 NP_001155244 NM_213621 NP_998786 NR_046363
|
| Function |
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. {ECO:0000269|PubMed:12867984, ECO:0000269|PubMed:9950429}.
|
| Subcellular Location |
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of the spleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta. {ECO:0000269|PubMed:10521471}.
|