XRCC6

Gene Symbol XRCC6
Entrez Gene 2547
Alt Symbol CTC75, CTCBF, G22P1, KU70, ML8, TLAA
Species Human
Gene Type protein-coding
Description X-ray repair complementing defective repair in Chinese hamster cells 6
Other Description 5'-dRP lyase Ku70|5'-deoxyribose-5-phosphate lyase Ku70|70 kDa subunit of Ku antigen|ATP-dependent DNA helicase 2 subunit 1|ATP-dependent DNA helicase II 70 kDa subunit|ATP-dependent DNA helicase II, 70 kDa subunit|CTC box binding factor 75 kDa subunit|CTC box-binding factor 75 kDa subunit|DNA repair protein XRCC6|Ku autoantigen p70 subunit|Ku autoantigen, 70kDa|X-ray repair cross-complementing protein 6|lupus Ku autoantigen protein p70|thyroid autoantigen 70kD (Ku antigen)|thyroid autoantigen 70kDa (Ku antigen)|thyroid-lupus autoantigen p70
Swissprots Q9UCQ3 Q6FG89 P12956 B1AHC8 Q9UCQ2
Accessions AAW34364 CAL00149 CAN36299 CBX87167 EAW60446 EAW60447 EAW60448 P12956 AK055786 BAG51575 AK293439 BAG56943 AK304580 BAG65368 AK315618 BAG37986 BC001583 BC008343 AAH08343 BC010034 AAH10034 BC012154 AAH12154 BC018259 AAH18259 BC072449 AAH72449 BI222708 BQ217843 BU584415 BU751953 BU902323 CD683757 CR456492 CAG30378 CR542219 CAG47015 CU013089 CAK54520 CU013377 CAK54819 DA647513 DA718140 DB057280 DC383335 DC386009 EU446892 ABZ92421 EU831485 ACE87172 EU831572 ACE86491 J04607 AAA61177 J04611 AAA51733 M32865 AAA36155 S38729 AAB22381 NM_001288976 NP_001275905 NM_001288977 NP_001275906 NM_001288978 NP_001275907 NM_001469 NP_001460
Function Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose- 5-phosphate at an abasic site near double-strand breaks. 5'-d
Subcellular Location Nucleus {ECO:0000269|PubMed:22442688}. Chromosome {ECO:0000269|PubMed:22442688}.
Top Pathways Non-homologous end-joining

Ku70 (D35) Antibody - 4103 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using Ku70 (D35) Antibody.

Ku70 (V540) Antibody - 4104 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa and COS cells using Ku70 (V540) Antibody.

Ku70 (D10A7) Rabbit mAb - 4588 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D10A7
Western blot analysis of extracts from various cell lines using Ku70 (D10A7) Rabbit mAb.

Ku-70 (3C3.11) - sc-12729 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ku-70 (3C3.11): sc-12729. Western blot analysis of Ku-70 expression in A-431 (A) and HeLa (B) whole cell lysates.

Ku-70 (H-6) - sc-365766 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ku-70 (H-6): sc-365766. Western blot analysis of Ku-70 expression in HeLa whole cell lysate.

Ku-70 (C-19) - sc-1486 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Ku-70 (C-19): sc-1486. Western blot analysis of Ku-70 expression in A-431 (A), HeLa (B) and C32 (C) whole cell lysates.

Ku-70 (E-5) - sc-17789 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ku-70 (E-5): sc-17789. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast tumor showing nuclear staining.

Ku-70 (G-4) - sc-166386 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ku-70 (G-4): sc-166386. Western blot analysis of Ku-70 expression in non-transfected: sc-117752 (A) and human Ku-70 transfected: sc-111431 (B) 293T whole cell lysates.

Ku-70 (G-7) - sc-55505 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ku-70 (G-7): sc-55505. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.

Ku-70 (H-308) - sc-9033 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Ku-70 (H-308): sc-9033. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast tumor showing nuclear staining.

Ku-70 (A-9) - sc-5309 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ku-70 (A-9): sc-5309. Western blot analysis of Ku-70 expression in HeLa (A) and C32 (B) whole cell lysates.

Ku-70 (M-19) - sc-1487 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Ku-70 (M-19): sc-1487. Western blot analysis of Ku-70 expression in A-431 (A), HeLa (B) and C32 (C) whole cell lysates.

Ku-70 (N3H10) - sc-56129 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ku-70 (N3H10): sc-56129. Western blot analysis of Ku-70 expression in K-562 (A), HeLa (B) and C32 (C) whole cell lysates.

Ku-70 (S5C11) - sc-56130 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ku-70 (S5C11): sc-56130. Western blot analysis of Ku-70 expression in K-562 (A), HeLa (B) and C32 (C) whole cell lysates.

Ku-70 (SPM273) - sc-56131 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ku-70 (SPM273): sc-56131. Western blot analysis of Ku-70 expression in non-transfected: sc-117752 (A) and human Ku-70 transfected: sc-128972 (B) 293T whole cell lysates.

Ku-70 (3F246) - sc-71469 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ku-70 (3F246): sc-71469. Western blot analysis of Ku-70 expression in HeLa whole cell lysate.

Ku-70 (15) - sc-135963 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/500 µl
Host Mouse
Clonality Monoclonal
Ku-70 (15): sc-135963. Immunofluorescence staining of HeLa cells showing nuclear staining.

Ku-70 (0.N.376) - sc-71470 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ku-70 (0.N.376): sc-71470. Western blot analysis of Ku-70 expression in non-transfected: sc-110760 (A) and human Ku-70 transfected: sc-112733 (B) 293 whole cell lysates.

Ku-70/Ku-86 (SPM274) - sc-65575 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Ku-70/Ku-86 (SPM274): sc-65575. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human tonsil tissue showing nuclear localization.

Ku-70/Ku-86 (3F247) - sc-71471 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Ku-70/Ku-86 (3F247): sc-71471. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human tonsil tissue showing nuclear localization.

Ku-70/Ku-86 (162) - sc-53632 from Santa Cruz Biotechnology

Host Mouse
Clonality Monoclonal
Ku-70/Ku-86 (162): sc-53632. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human tonsil tissue showing nuclear localization.

Anti-Ku70 + Ku80 antibody - ab53126 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Ku70 + Ku80 antibody (ab53126) at 1/300 dilutionLane 1 : LoVo cell extractLane 2 : LoVo cell extract with immunising peptide

Anti-Ku70 + Ku80 antibody [162] - ab80828 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 162
Formalin-fixed, paraffin-embedded human tonsil tissue stained with ab80828 at 1-2µg/ml using peroxidase-conjugate and AEC chromogen. Note nuclear staining of the cells.

Anti-Ku70 + Ku80 antibody [SPM274], prediluted - ab54269 from Abcam

Prices $370.00
Sizes 7 ml
Host Mouse
Clonality Monoclonal
Clone SPM274
Human tonsil stained with Ku70 + Ku80 antibody [SPM274] (ab54269)

Anti-Ku70 + Ku80 antibody - C-terminal - ab166822 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Ku70 + Ku80 antibody - C-terminal (ab166822) at 1/500 dilutionLane 1 : LoVo cell lysateLane 2 : LoVo cell lysate with synthesized peptide
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