| Gene Symbol | Btk |
|---|---|
| Entrez Gene | 12229 |
| Alt Symbol | AI528679, xid |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | Bruton agammaglobulinemia tyrosine kinase |
| Other Description | ATK|B-cell progenitor kinase|BPK|Bruton's tyrosine kinase|Tyrosine-protein kinase BTK (Brutons tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB)|X-linked immune deficiency|agammaglobulinaemia tyrosine kinase|agammaglobulinemia tyrosine kinase|bruton tyrosine kinase|kinase EMB|tyrosine-protein kinase BTK |
| Swissprots | Q61365 P35991 |
| Accessions | AAB47246 EDL20395 P35991 BC053392 AAH53392 BY596531 CJ044967 DT921900 L08967 AAA37316 L10627 L29788 AAA66943 XM_006528483 XP_006528546 XM_006528484 XP_006528547 XM_006528485 XP_006528548 NM_013482 NP_038510 |
| Function | Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. E |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11120822}. Cell membrane {ECO:0000269|PubMed:11120822}; Peripheral membrane protein {ECO:0000269|PubMed:11120822}. Nucleus {ECO:0000269|PubMed:11120822}. Note=In steady state, BTK is predominantly cytosolic. Following B-cell receptor (BCR) engagement by antigen, translocates to the plasma membrane through its PH domain. Plasma membrane localization is a critical step in the activation of BTK. A fraction of BTK also shuttles between the nucleus and the cytoplasm, and nuclear export is mediated by the nuclear export receptor CRM1. {ECO:0000250}. |
| Top Pathways | B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Primary immunodeficiency, Osteoclast differentiation |