KMT2D

Gene Symbol	KMT2D
Entrez Gene	8085
Alt Symbol	AAD10, ALR, CAGL114, KABUK1, KMS, MLL2, MLL4, TNRC21
Species	Human
Gene Type	protein-coding
Description	lysine (K)-specific methyltransferase 2D
Other Description	ALL1-related protein|Kabuki make-up syndrome|Kabuki mental retardation syndrome|histone-lysine N-methyltransferase 2D|histone-lysine N-methyltransferase MLL2|lysine N-methyltransferase 2D|myeloid/lymphoid or mixed-lineage leukemia 2|trinucleotide repeat containing 21
Swissprots	O14686 O14687
Accessions	EAW58034 EAW58035 EAW58036 O14686 AB209494 BAD92731 AF010403 AAC51734 AF010404 AAC51735 AL359940 AW997729 BC039197 AAH39197 BC040663 BF739070 BF876885 BF993837 BI031059 BX956541 CR749712 U80756 AAB91448 X85325 Y08267 CAA69593 XM_005269162 XP_005269219 XM_006719614 XP_006719677 XM_006719616 XP_006719679 XM_011538770 XP_011537072 XM_011538771 XP_011537073 XM_011538772 XP_011537074 XM_011538773 XP_011537075 XM_011538774 XP_011537076 XM_011538775 XP_011537077 XM_011538776 XP_011537078 XR_944740 NM_003482 NP_003473
Function	Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:17851529}.
Subcellular Location	Nucleus {ECO:0000305}.
Tissue Specificity	Expressed in most adult tissues, including a variety of hematoipoietic cells, with the exception of the liver.
Top Pathways	Lysine degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human KMT2D / MLL2 peptide - ab23289 from Abcam Category Peptide Species Human

Human KMT2D / MLL2 protein fragment - ab152839 from Abcam Category Protein Source Wheat germ Species Human

KMT2D / MLL2 Antibody Blocking Peptide - LS-E25459 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human KMT2D Protein - H00008085-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

AKR1A1 blocking peptide - GTX11802-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat, Bovine

MLL2 blocking peptide - GTX15962-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

MLL4 blocking peptide - GTX89763-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

Human ALR (His Tag) protein - orb179769 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Human Cells Species Human

MLL4 Blocking Peptide - abx063614 from Abbexa Category Peptide Species Human, Mouse, Rat

KMT2B/MLL2 Peptide - AC21-0288-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

MLL2 - H00008085-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

MLL2 - H00008085-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

MLL2 Peptide - 45-890P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

Recombinant MLL2-SET protein - 31420 from ActiveMotif Category Protein Prices $395.00, $3,200.00 Sizes 20 μg, 1 mg Source E. coli Species Human

Human GFER / ALR Protein (His Tag) - 15278-H08H-100 from Sino Biological Category Protein Prices $348.00, $348.00 Sizes 20 µg, 100 µg Source Human Cells Species Human

Recombinant Human Histone-lysine N-methyltransferase MLL2(MLL2) ,partial - CSB-YP014628HU CSB-EP014628HU CSB-BP014628HU CSB-MP014628HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MLL2, Peptide - MBS425257 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

Recombinant Human KMT2D Complex, His-tagged - KMT2D-129H from Creative Biomart Category Protein Source E.coli Species Human

KMT2B Protein - NBP1-87590PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

KMT2D Recombinant Protein Antigen - NBP1-89123PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Recombinant MLL2 Complex - 31498 from ActiveMotif Prices $415.00, $3,500.00 Sizes 20 µg, 1 mg Source E. coli Species Human

MLL2-Antibody-C-term-Blocking-Peptide - BP6183a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MLL2 Peptide, Human - M34GP09564H from Creative Peptides Category Peptide Source Synthetic. Species Human

MLL4 Peptide, Human - M34GP09566H from Creative Peptides Category Peptide Source Synthetic. Species Human

Histone-lysine N-methyltransferase MLL2 (MLL2), partial, Recombinant Protein - MBS1066459 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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