IL33

Gene Symbol	IL33
Entrez Gene	90865
Alt Symbol	C9orf26, DVS27, IL1F11, NF-HEV, NFEHEV
Species	Human
Gene Type	protein-coding
Description	interleukin 33
Other Description	DVS27-related protein|IL-1F11|IL-33|interleukin-1 family member 11|interleukin-33|nuclear factor for high endothelial venules|nuclear factor from high endothelial venules
Swissprots	B4E1Q9 B2R8L1 O95760 E7EAX4 B4DJ35 Q2YEJ5 D3DRI5
Accessions	EAW58748 EAW58749 EAW58750 EAW58751 O95760 AB024518 BAA75892 AI610794 AK295908 BAG58697 AK303943 BAG64871 AK313414 BAG36208 AL080211 AY905581 AAX86998 BC047085 AAH47085 BQ878541 CR407619 CAG28547 DB477860 HQ641439 ADR77828 XM_005251626 XP_005251683 XM_005251627 XP_005251684 XM_011518059 XP_011516361 XM_011518060 XP_011516362 XM_011518061 XP_011516363 NM_001199640 NP_001186569 NM_001199641 NP_001186570 NM_033439 NP_254274
Function	Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528). {ECO:0000269|PubMed:16286016, ECO:0000269|PubMed:17853410, ECO:0000269|PubMed:18836528}.
Subcellular Location	Nucleus. Chromosome. Cytoplasmic vesicle, secretory vesicle. Secreted. Note=Associates with heterochromatin and mitotic chromosomes. Translocation from the nucleus occurs upon biomechanical strain, depends on an intact microtubule network, and is ATP-dependent.
Tissue Specificity	Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta. {ECO:0000269|PubMed:12819012}.
Top Pathways	Cytosolic DNA-sensing pathway, Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human IL33 full length protein - ab155721 from Abcam Category Protein Prices $192.00 Sizes 10 µg Source E. coli Species Human

Active human IL33 full length protein - ab109065 from Abcam Category Protein Prices $315.00 Sizes 10 µg Source E. coli Species Human

Active human IL33 full length protein - ab109139 from Abcam Category Protein Prices $315.00 Sizes 10 µg Source HEK 293 cells Species Human

Active human IL33 full length protein - ab109154 from Abcam Category Protein Prices $352.00 Sizes 10 µg Source E. coli Species Human

Active human IL33 protein fragment - ab82121 from Abcam Category Protein Prices $110.00, $200.00 Sizes 2 µg, 10 µg Source E. coli Species Human

Active mouse IL33 full length protein - ab157059 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source E. coli Species Mouse

Active mouse IL33 full length protein - ab109164 from Abcam Category Protein Prices $352.00 Sizes 10 µg Source E. coli Species Mouse

Active mouse IL33 full length protein - ab181951 from Abcam Category Protein Prices $1,457.00 Sizes 100 µg Source E. coli Species Mouse

Active mouse IL33 full length protein - ab187237 from Abcam Category Protein Prices $265.00 Sizes 10 µg Source E. coli Species Mouse

Active rat IL33 protein fragment - ab200250 from Abcam Category Protein Prices $107.00 Sizes 2 µg Source E. coli Species Rat

Human IL33 full length protein - ab166877 from Abcam Category Protein Source E. coli Species Human

Human IL33 peptide - ab101293 from Abcam Category Peptide

Human IL33 protein fragment - ab72893 from Abcam Category Protein Source E. coli Species Human

Human IL33 protein fragment - ab82836 from Abcam Category Protein Source E. coli Species Human

Human IL33 protein fragment - ab82840 from Abcam Category Protein Source E. coli Species Human

Human IL33 protein fragment - ab151346 from Abcam Category Protein Source E. coli Species Human

Mouse IL33 full length protein - ab187455 from Abcam Category Protein Source E. coli Species Mouse

Mouse IL33 protein fragment - ab69516 from Abcam Category Protein Source E. coli Species Mouse

IL-33 Antibody Blocking Peptide - LS-E3211 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IL-33 Antibody Blocking Peptide - LS-E18420 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IL-33 Antibody Blocking Peptide - LS-E30366 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

IL-33 Antibody Blocking Peptide - LS-E30367 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

IL-33 Antibody Blocking Peptide - LS-E28065 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human IL-33 Protein - NBP2-34871 from Novus Biologicals Category Protein Prices $69.00, $169.00, $4,629.00 Sizes 2 µg, 10 µg, 1 mg Source E. coli Species Human

IL-33 Partial Recombinant Protein - H00090865-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

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