ESR1

Gene Symbol	ESR1
Entrez Gene	2099
Alt Symbol	ER, ESR, ESRA, ESTRR, Era, NR3A1
Species	Human
Gene Type	protein-coding
Description	estrogen receptor 1
Other Description	ER-alpha|estradiol receptor|estrogen nuclear receptor alpha|estrogen receptor|estrogen receptor alpha E1-E2-1-2|estrogen receptor alpha E1-N2-E2-1-2|nuclear receptor subfamily 3 group A member 1
Swissprots	P03372 Q6MZQ9 Q14276 Q13511 Q9UDZ7 Q9UIS7 Q9NU51 Q5T5H7
Accessions	AAG42501 AAQ91815 AFV77693 AFV77694 AGC74339 CAA05557 CAA05558 CAA05559 CAA05560 CAA44322 CAL40514 EAW47740 EAW47741 P03372 AB307713 BAH02304 AB588629 BAJ41265 AB588630 BAJ41266 AB685814 BAM62930 AB685815 BAM62931 AB685816 BAM62932 AB685817 BAM62933 AB685818 BAM62934 AB685819 BAM62935 AB685820 BAM62936 AF120105 AAD23565 AF258449 AAG41358 AF258450 AAG41359 AF258451 AAG41360 AK293019 BAF85708 AK304600 BAG65386 AK304833 BAG65577 AK309580 AK311064 AK313644 AY750962 AAW69860 BC128573 AAI28574 BC128574 AAI28575 BE084831 BX640939 CAE45969 DA329077 DB285906 DQ163909 ABA41493 EF491789 EU447161 EU921455 ACH41916 EU930361 ACH61905 EU982838 ACH73261 EU982839 ACH73262 EU982840 ACH73263 FJ011556 ACI06210 FJ011557 ACI06211 FJ011558 ACI06212 FJ011559 ACI06213 FJ011560 ACI06214 FJ147552 ACI01724 FJ147553 ACI01725 FJ147554 ACI01726 FJ147555 ACI01727 FJ147556 ACI01728 FJ147557 ACI01729 FJ147558 ACI01730 FJ169500 ACI04255 FJ169501 ACI04256 FJ169502 ACI04257 FJ169503 ACI04258 FJ169504 ACI04259 FJ668387 ACN41854 FJ712305 ACN66633 FJ712306 ACN66634 FJ712307 ACN66635 FJ716811 ACN89822 FJ716812 ACN89823 FJ716813 ACN89824 FJ716814 ACN89825 FJ716815 ACN89826 GQ366704 ACU29456 GQ389792 ACV04432 GQ411250 ACV41785 GQ411251 ACV41786 GQ411252 ACV41787 GQ411253 ACV41788 GQ411254 ACV41789 GQ411255 ACV41790 GQ411256 ACV41791 GQ411257 ACV41792 GQ411258 ACV41793 GQ438789 ACV88147 GQ438790 ACV88148 GQ438791 ACV88149 GQ438792 ACV88150 GQ438793 ACV88151 JF810888 AEP43755 M12674 AAA52399 M69297 AAA58462 S79911 AAB21301 S80316 AAB35900 U47678 AAB00115 U68067 AAC51874 U68068 AAC51875 X03635 CAA27284 X73067 CAA51528 X74439 X86816 Z75126 CAA99436 XM_006715374 XP_006715437 XM_006715375 XP_006715438 XM_011535543 XP_011533845 XM_011535544 XP_011533846 XM_011535545 XP_011533847 XM_011535546 XP_011533848 XM_011535547 XP_011533849 XM_011535548 XP_011533850 XM_011535549 XP_011533851 NM_000125 NP_000116 NM_001122740 NP_001116212 NM_001122741 NP_001116213 NM_001122742 NP_001116214 NM_001291230 NP_001278159 NM_001291241 NP_001278170
Function	Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF- kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA- binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B r
Subcellular Location	Nucleus. Golgi apparatus. Cell membrane. Note=Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs. Associated with the plasma membrane when palmitoylated.
Tissue Specificity	Widely expressed. Isoform 3 is not expressed in the pituitary gland. {ECO:0000269|PubMed:10970861}.
Top Pathways	Endocrine and other factor-regulated calcium reabsorption, Prolactin signaling pathway, Estrogen signaling pathway, Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SimpleChIP ® Human ESR1 Promoter Primers - 9673 from Cell Signaling Technology Category ChIP Kit Prices $102.00 Sizes 500 µl (250 PCR reactions)

Estrogen Receptor Alpha ELISA Kit - ab128499 from Abcam Category ELISA Kit Prices $740.00 Sizes 1 x 96 tests Sensitivity > 600 ng/well Range 600 ng/well - 10000 ng/well

CytoPainter Lysosome/ER/Nuclear Staining Reagent - ab139488 from Abcam Category Cellular Assay Prices $386.00 Sizes 1000 tests

Rat ER Alpha / Estrogen Receptor ELISA Kit (Sandwich ELISA) - LS-F4328 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.126 ng/ml Range 0.625-40 ng/ml

Human ER Alpha / Estrogen Receptor ELISA Kit (Sandwich ELISA) - LS-F4409 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.625 ng/ml Range 0.625-40 ng/ml

Mouse ER Alpha / Estrogen Receptor ELISA Kit (Sandwich ELISA) - LS-F6267 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.146 ng/ml Range 0.625-40 ng/ml

Mouse/Human/Rat Phospho-ER Alpha / Estrogen Receptor (Ser104) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1501 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.625-40 ng/ml

Mouse/Human/Rat Phospho-ER Alpha / Estrogen Receptor (Ser106) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1502 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.625-40 ng/ml

Mouse/Human Phospho-ER Alpha / Estrogen Receptor (Ser118) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1503 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.625-40 ng/ml

Human Phospho-ER Alpha / Estrogen Receptor (Ser167) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1504 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.625-40 ng/ml

Mouse/Human ER Alpha / Estrogen Receptor ELISA Kit (Cell-Based ELISA) - LS-F1976 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.625-40 ng/ml

Mouse/Human Phospho-ER Alpha / Estrogen Receptor (Ser118) ELISA Kit (DNA-Binding Phosphorylation ELISA) - LS-F919 from LifeSpan Bioscience Category ELISA Kit Prices $750.00 Sizes 1 plate Range 0.625-40 ng/ml

Mouse/Human ER Alpha / Estrogen Receptor ELISA Kit (DNA-Binding ELISA) - LS-F920 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Range 0.625-40 ng/ml

Mouse/Human Phospho-ER Alpha / Estrogen Receptor (Tyr537) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1166 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.625-40 ng/ml

Rat ER Alpha / Estrogen Receptor ELISA Kit (Sandwich ELISA) - LS-F11393 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 ng/ml Range 0.625-40 ng/ml

Chicken ER Alpha / Estrogen Receptor ELISA Kit (Sandwich ELISA) - LS-F11395 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.312 Range 0.625-40 ng/ml

Mouse ER Alpha / Estrogen Receptor ELISA Kit (Sandwich ELISA) - LS-F11394 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.625-40 ng/ml

Rabbit anti-Estrogen Receptor Alpha Antibody, Affinity Purified - PLA0113 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

Rabbit anti-Phospho Estrogen Receptor Alpha (S305) Antibody, Affinity Purified - PLA0121 from Sigma-Aldrich

Human Total ER alpha/NR3A1 DuoSet IC ELISA - DYC5715-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates) Range 15.60 - 1,000 pg/mL

Human Total ER alpha/NR3A1 DuoSet IC, 5 Plate - DYC5715-5 from R&D Systems Category ELISA Kit

Human Phospho-ER alpha/NR3A1 (S118) DuoSet IC ELISA, 2 Plate - DYC5954-2 from R&D Systems Category ELISA Kit Prices $329.00 Sizes 1 kit (for 2 Plates) Range 31.20 - 2,000 pg/mL

Human ERa ELISA Kit - abx151438 from Abbexa Category ELISA Kit Sensitivity 0.223 ng/ml Range 0.625 ng/ml - 40 ng/ml

Human Estradiol Receptor ELISA Kit - abx052723 from Abbexa Category ELISA Kit

Human Estrogen Receptor ELISA kit - abx050063 from Abbexa Category ELISA Kit Sensitivity < 10 pg/ml Range 0.3 ng/ml-10 ng/ml

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