SENP1

Gene Symbol	SENP1
Entrez Gene	29843
Alt Symbol	SuPr-2
Species	Human
Gene Type	protein-coding
Description	SUMO1/sentrin specific peptidase 1
Other Description	SUMO1/sentrin specific protease 1|sentrin-specific protease 1|sentrin/SUMO-specific protease SENP1
Swissprots	Q86XC8 A8K7P5 Q9P0U3
Accessions	EAW57971 EAW57972 Q9P0U3 AF149770 AAF31171 AK292060 BAF84749 AK312874 AL582855 BC045639 AAH45639 BI560893 BX537920 CAD97903 BX640784 CAE45874 XM_006719361 XP_006719424 XM_006719362 XP_006719425 XM_011538244 XP_011536546 XM_011538245 XP_011536547 NM_001267594 NP_001254523 NM_001267595 NP_001254524 NR_051991 NR_051992 NM_014554
Function	Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. {ECO:0000269|PubMed:10652325, ECO:0000269|PubMed:15199155, ECO:0000269|PubMed:16253240, ECO:0000269|PubMed:16553580, ECO:0000269|PubMed:21829689, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:23160374}.
Subcellular Location	Nucleus. Cytoplasm. Note=Shuttles between cytoplasm and nucleus.
Tissue Specificity	Highly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver, ovary and small intestine. {ECO:0000269|PubMed:15487983}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human SENP1 protein fragment - ab188689 from Abcam Category Protein Prices $232.00 Sizes 50 µg Source E. coli Species Human

Active human SENP1 protein fragment - ab125846 from Abcam Category Protein Source E. coli Species Human

SENP1 Antibody Blocking Peptide - LS-E1571 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SENP1 Antibody Blocking Peptide - LS-E1579 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SENP1 Antibody Blocking Peptide - LS-E19886 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SENP1 Protein - H00029843-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SENP1 Peptide - P0295 from Novus Biologicals Category Peptide Species Human

SENP1 Peptide - P0294 from Novus Biologicals Category Peptide Species Human

SENP1-Antibody-C-term-Blocking-Peptide - BP1231a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SENP1-Antibody-N-term-Blocking-Peptide - BP1230a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human His6-SENP1 Catalytic Domain, CF - E-700-050 from R&D Systems Category Protein Source E. coli-derived, Contains an N-terminal Gly-Ser-Ser and 6-His tag

SENP1 protein - orb197641 from Biorbyt Category Protein Prices $255.00, $391.00, $519.00 Sizes 10 μg, 50 μg, 100 μg Species Human

SENP1 peptide - orb218506 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human

SENP1 Blocking Peptide - 33R-7308 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SENP1 Blocking Peptide - abx063837 from Abbexa Category Peptide Species Human, Bovine, Dog, Monkey

SENP1 - H00029843-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SENP1 - H00029843-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human SENP1 protein - 230-00545-10 from RayBiotech Category Protein Prices $110.00 Sizes 10 µg Source Escherichia coli (E.coli) Species Human

Recombinant Human SENP1 protein - 230-00545-50 from RayBiotech Category Protein Prices $224.00 Sizes 50 µg Source Escherichia coli (E.coli) Species Human

Recombinant Human SENP1 protein - 230-00545-100 from RayBiotech Category Protein Prices $336.00 Sizes 100 µg Source Escherichia coli (E.coli) Species Human

SENP1 fusion protein - Ag18708 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

SENP1 fusion protein - ag18028 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human SENP1, GST-tagged - SENP1-686H from Creative Biomart Category Protein Source E. coli.

Recombinant Human SENP1, His-tagged - SENP1-687H from Creative Biomart Category Protein Source E. Coli

Recombinant Human SENP1 Catalytic Domain, His-tagged - SENP1-688H from Creative Biomart Category Protein

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