| Gene Symbol |
SOAT1
|
| Entrez Gene |
6646
|
| Alt Symbol |
ACACT, ACAT, ACAT-1, ACAT1, SOAT, STAT
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sterol O-acyltransferase 1
|
| Other Description |
acyl-coenzyme A:cholesterol acyltransferase 1|sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1
|
| Swissprots |
Q5T0X4 B4DU95 A9Z1V7 P35610 Q8N1E4 A8K3P4 A6NC40
|
| Accessions |
EAW91043 EAW91044 P35610 AK026611 AK290659 BAF83348 AK294047 BAG57399 AK300551 BAG62257 AK310920 AK316401 BAH14772 AL833625 BC028940 AAH28940 BQ182606 DC344271 DQ891807 ABM82733 DQ894991 ABM85917 L21934 AAC37532 XM_011509911 XP_011508213 XM_011509912 XP_011508214 NM_001252511 NP_001239440 NM_001252512 NP_001239441 NM_003101 NP_003092 NR_045530
|
| Function |
Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:16154994}; Multi-pass membrane protein {ECO:0000269|PubMed:16154994}.
|
| Top Pathways |
Steroid biosynthesis
|
![Western Blot: ACAT Overexpression Lysate (Adult Normal) [NBP2-10868] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ACAT.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3167_ACAT%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10868-img0001.jpg)