FBL

Gene Symbol FBL
Entrez Gene 2091
Alt Symbol FIB, FLRN, RNU3IP1
Species Human
Gene Type protein-coding
Description fibrillarin
Other Description 34 kDa nucleolar scleroderma antigen|34-kD nucleolar scleroderma antigen|RNA, U3 small nucleolar interacting protein 1|histone-glutamine methyltransferase|rRNA 2'-O-methyltransferase fibrillarin
Swissprots Q6IAT5 B5BUE8 O75259 P22087 Q9UPI6
Accessions AAC28913 AAD15623 EAW56925 P22087 AB451384 BAG70198 AI085380 AK296950 BAG59496 AK308649 BC015218 AAH15218 BC019260 AAH19260 BC019609 AAH19609 BG831506 BT006830 AAP35476 BT020144 AAV38946 CR457069 CAG33350 DQ892314 ABM83240 DQ895517 ABM86443 M59849 AAA52453 X56597 CAA39935 XM_005258651 XP_005258708 XM_011526623 XP_011524925 XM_011548798 XP_011547100 XM_011548799 XP_011547101 NM_001436 NP_001427
Function S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239). {ECO:0000269|PubMed:24352239}.
Subcellular Location Nucleus, nucleolus {ECO:0000269|PubMed:14583623, ECO:0000269|PubMed:2026646, ECO:0000269|PubMed:2414294, ECO:0000269|PubMed:24352239}. Note=Fibrillar region of the nucleolus.
Top Pathways Ribosome biogenesis in eukaryotes

Fibrillarin CRISPR/Cas9 KO Plasmid (h) - sc-400741 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fibrillarin HDR Plasmid (h) - sc-400741-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fibrillarin Double Nickase Plasmid (h) - sc-400741-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fibrillarin Double Nickase Plasmid (h2) - sc-400741-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fibrillarin CRISPR Activation Plasmid (h) - sc-400741-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fibrillarin CRISPR Activation Plasmid (h2) - sc-400741-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fibrillarin Lentiviral Activation Particles (h) - sc-400741-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fibrillarin Lentiviral Activation Particles (h2) - sc-400741-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fibrillarin siRNA (h) - sc-37883 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Fibrillarin shRNA Plasmid (h) - sc-37883-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Fibrillarin shRNA (h) Lentiviral Particles - sc-37883-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Fibrillarin RNAi - H00002091-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU014721 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® esiRNA - EHU038951 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8501 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8501 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

FBL siRNA (Human) - CRH1455 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FBL - MBS8238977 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Fibrillarin CRISPR/Cas9 KO Plasmid (h2) - sc-400741-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Fibrillarin HDR Plasmid (h2) - sc-400741-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human FBL (NM_001436.3) - SHH292653 from Creative biogene

Category siRNA
Species Reactivities Human

Human FBL siRNA - orb261957 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FBL shRNA Plasmid (Human) - CHH1455 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FBL miRNA 3'UTR clone - MiUTR3H-00789 from Creative biogene

Species Reactivities Human
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