DPYSL2

Gene Symbol DPYSL2
Entrez Gene 1808
Alt Symbol CRMP-2, CRMP2, DHPRP2, DRP-2, DRP2, N2A3, ULIP-2, ULIP2
Species Human
Gene Type protein-coding
Description dihydropyrimidinase-like 2
Other Description collapsin response mediator protein hCRMP-2|dihydropyrimidinase-related protein 2|unc-33-like phosphoprotein 2
Swissprots Q16555 B4DR31 A8K5H2 D3DSS7 O00424
Accessions BAA86991 CAR95650 CAT03389 EAW63573 EAW63574 Q16555 AB209195 BAD92432 AB370194 BAF94338 AB370195 BAF94339 AK092377 BAC03872 AK223557 BAD97277 AK291287 BAF83976 AK299077 BAG61143 BC056408 AAH56408 BC067109 AAH67109 BP222303 BX461557 BX463316 BX647115 D78013 BAA11191 DA649686 DC333865 DC344356 U17279 AAA93202 X91250 NM_001197293 NP_001184222 NM_001244604 NP_001231533 NM_001386 NP_001377
Function Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. {ECO:0000269|PubMed:11477421, ECO:0000269|PubMed:15466863, ECO:0000269|PubMed:20801876}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:20801876}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20801876}. Membrane {ECO:0000269|PubMed:20801876}. Note=Tightly but non-covalently associated with membranes.
Tissue Specificity Ubiquitous.
Top Pathways Axon guidance

Phospho-CRMP-2 (Thr514) Antibody - 9397 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from PC12 cells, untreated or λ phosphatase treated, using Phospho-CRMP-2 (Thr514) Antibody (upper) or CRMP-2 Antibody #9393 (lower).

CRMP-2 Antibody - 9393 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from mouse and rat brain using CRMP-2 Antibody.

CRMP-2 (E-9) - sc-376739 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CRMP-2 (E-9): sc-376739. Western blot analysis of CRMP-2 expression in non-transfected: sc-117752 (A) and human CRMP-2 transfected: sc-116677 (B) 293T whole cell lysates.

CRMP-2 (C-16) - sc-25895 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CRMP-2 (C-16): sc-25895. Immunoperoxidase staining of formalin fixed, paraffin-embedded human fallopian tube tissue showing cytoplasmic staining of glandular cells.

CRMP-2 (D-17) - sc-25893 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CRMP-2 (1B1) - sc-101348 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µl ascites
Host Mouse
Clonality Monoclonal
CRMP-2 (1B1): sc-101348. Western blot analysis of CRMP-2 expression in non-transfected: sc-117752 (A) and human CRMP-2 transfected: sc-116677 (B) 293T whole cell lysates.

Anti-CRMP2 (phospho S522) antibody - ab193226 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CRMP2 (phospho S522) antibody (ab193226) at 1/500 dilutionLane 1 : HuvEc cell lysate with antigen-specific peptideLane 2 : HuvEc cell lysate

Anti-CRMP2 (phospho T509) antibody - ab192799 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CRMP2 (phospho T509) antibody (ab192799) at 1/500 dilutionLane 1 : HT29 cell extractLane 2 : HT29 cell extract with antigen-specific peptide

Anti-CRMP2 (phospho T509) antibody - C-terminal - ab138357 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CRMP2 (phospho T509) antibody - C-terminal (ab138357) at 1/500 dilution + Heat shocked HT-29 cell extract at 30 µg

Anti-CRMP2 (phospho T514 + S518) antibody - ab75035 from Abcam

Host Sheep
Clonality Polyclonal

Anti-CRMP2 (phospho T514) antibody - ab62478 from Abcam

Prices $390.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab62478, at 1/50 dilution, staining CRMP2 in paraffin embedded human brain tissue by Immunohistochemsitry in the absence (left image) or presence (right image) of the immunising peptide.

Anti-CRMP2 (phospho T514) antibody - ab85934 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CRMP2 (phospho T514) antibody (ab85934) at 1 µg/mlLane 1 : Brain (Human) Tissue Lysate - adult normal tissue (ab29466)Lane 2 : Brain (Mouse) Tissue Lysate Lane 3 : Brain (Rat) Tissue Lysate Lane 4 : Brain (Human) Tissue Lysate - adult normal tissue (ab29466) with Human Dihydropyrimidinase-related protein 2 Synth (508 - 520) (Phosphorylated T 514)Lane 5 : Brain (Mouse) Tissue Lysate with Human Dihydropyrimidinase-related protein 2 Synth (508 - 520) (Phosphorylated T 514)Lane 6 : Brain (Rat) Tissue Lysate with Human Dihydropyrimidinase-related protein 2 Synth (508 - 520) (Phosphorylated T 514)Lane 7 : Brain (Human) Tissue Lysate - adult normal tissue (ab29466) with Human Dihydropyrimidinase-related protein 2 Synth (508 - 520) (Non-Modified)Lane 8 : Brain (Mouse) Tissue Lysate with Human Dihydropyrimidinase-related protein 2 Synth (508 - 520) (Non-Modified)Lane 9 : Brain (Rat) Tissue Lysate with Human Dihydropyrimidinase-related protein 2 Synth (508 - 520) (Non-Modified)L

Anti-CRMP2 (phospho T514) antibody [EPR7876] - ab129066 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7876
All lanes : Anti-CRMP2 (phospho T514) antibody [EPR7876] (ab129066) at 1/1000 dilutionLane 1 : Human fetal brain lysate, untreated Lane 2 : Human fetal brain lysate, treated with Lambda PhosphataseLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-CRMP2 antibody - ab62661 from Abcam

Prices $382.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CRMP2 antibody (ab62661) at 1/10000 dilutionLane 1 : Mouse brain (S1 fraction)Lane 2 : Rat brain (S1 fraction)Lane 3 : HeLa cellsLane 4 : HEK-293T cells transfected with human CRMP2Lane 5 : Untransfected HEK-293T cellsLane 6 : Mouse brain (S1 fraction): with CRMP2 immunizing peptide at 10 µg/mlSecondaryGoat Anti-Rabbit IgG, Peroxidase conjugatedeveloped using the ECL technique

Anti-CRMP2 antibody - ab36201 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CRMP2 antibody (ab36201)Lane 1 : E.coli transformed with cDNA of human CRMP1Lane 2 : E.coli transformed with cDNA of human CRMP2Lane 3 : E.coli transformed with cDNA of human CRMP3Lane 4 : E.coli transformed with cDNA of human CRMP4Lane 5 : E.coli transformed with cDNA of human CRMP5

Anti-CRMP2 antibody - ab118842 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CRMP2 antibody (ab118842) at 1/500 dilutionLane 1 : A549 cell extracts, treated with EGF (200ng/ml for 30min)Lane 2 : A549 cell extracts, treated with EGF (200ng/ml for 30min) with synthesized peptide

Anti-CRMP2 antibody - ab75036 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-CRMP2 antibody - ab117870 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CRMP2 antibody - ab54546 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CRMP2 antibody [1B1] - ab62539 from Abcam

Prices $379.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1B1
Anti-CRMP2 antibody [1B1] (ab62539) at 1/2500 dilution + CRMP2 antibody [1B1] (ab62539) at 1/2500 dilution + SK N BE (Human neuroblastoma) Whole Cell Lysate at 10 µgSecondaryGoat polyclonal to Mouse IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

Anti-CRMP2 antibody [33CT11.40.3] - ab157400 from Abcam

Host Mouse
Clonality Monoclonal
Clone 33CT11.40.3

Anti-CRMP2 antibody [EPR7792] - ab129082 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7792
Overlay histogram showing SH-SY5Y cells stained with ab129082 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab129082, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-DPYSL2 / CRMP2 Antibody (C-Terminus) - LS-C42568 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Goat
Clonality Polyclonal

Anti-DPYSL2 / CRMP2 Antibody (aa463-492, clone 33CT11.40.3) IHC-plus™ - LS-B3616 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 33CT11.40.3
Anti-CRMP-2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3616 dilution 1:200.

Anti-DPYSL2 / CRMP2 Antibody (C-Terminus) - LS-C46914 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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