EPHA4

Gene Symbol EPHA4
Entrez Gene 2043
Alt Symbol HEK8, SEK, TYRO1
Species Human
Gene Type protein-coding
Description EPH receptor A4
Other Description EK8|EPH-like kinase 8|TYRO1 protein tyrosine kinase|ephrin type-A receptor 4|receptor protein-tyrosine kinase HEK8|tyrosine-protein kinase TYRO1|tyrosine-protein kinase receptor SEK
Swissprots B7Z6Q8 A8K2P1 P54764 Q2M380 B2R601
Accessions AAX81994 AAY24283 AAY24284 CAJ32200 CAT16933 CCQ77687 CCQ77696 CCQ77705 CCQ77714 CDH48193 CDH61615 CDH61669 CDH61688 CDH88986 CDH92524 CDH92538 CDH92549 CDH92796 CDH92893 CDI44668 CDI44677 EAW70785 EAW70786 P54764 AA987900 AF075040 AK225181 AK290306 BAF82995 AK300772 BAH13344 AK312380 BAG35298 AL603465 BC016981 BC026327 AAH26327 BC105000 AAI05001 BC105002 AAI05003 BM676153 BM679073 BM680394 BM712812 BM724253 BQ009361 DA451606 L36645 AAA74246 XM_005246374 XP_005246431 NM_001304536 NP_001291465 NM_001304537 NP_001291466 NM_004438 NP_004429
Function Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. I
Subcellular Location Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Early endosome {ECO:0000250}. Note=Clustered upon activation and targeted to early endosome. {ECO:0000250}.
Tissue Specificity Ubiquitous.
Top Pathways Axon guidance

EphA4 (D-4) - sc-365503 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
EphA4 (D-4): sc-365503. Western blot analysis of EphA4 expression in MOLT-4 (A), Ramos (B), Hep G2 (C), SKBR-3 (D), HL-60 (E) and K-562 (F) whole cell lysates.

EphA4 (A-20) - sc-922 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
EphA4 (A-20): sc-922. Western blot analysis of EphA4 expression in rat brain tissue extract.

EphA4 (H-55) - sc-25457 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

EphA4 (S-20) - sc-921 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
EphA4 (S-20): sc-921. Western blot analysis of EphA4 expression in rat brain extract.

EphA4 (35) - sc-135897 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/500 µl
Host Mouse
Clonality Monoclonal
EphA4 (35): sc-135897. Western blot analysis of EphA4 expression in non-transfected: sc-117752 (A) and mouse EphA4 transfected: sc-120067 (B) 293T whole cell lysates.

Anti-Eph receptor A4 (phospho Y596) antibody - ab193214 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Eph receptor A4 (phospho Y596) antibody (ab193214) at 1/500 dilutionLane 1 : Jurkat cell extract with antigen-specific peptideLane 2 : Jurkat cell extract

Anti-Eph receptor A4 antibody - ab5396 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Eph receptor A4 antibody (ab5396) at 1/1000 dilutionLane 1 : HeLa Cell LysateLane 2 : NCI-H460 Cell LysateLane 3 : Mouse NIH3T3 Cell LysateLane 4 : Human ovary tissue LysateLysates/proteins at 35 µg per lane.SecondaryGoat anti-rabbit IgG H+L HRP conjugated at 1/10000 dilution

Anti-Eph receptor A4 antibody - ab5389 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent staining of methanol/acetone fixed human stem cells for Eph4A (blue) and endothelial Lectin(red). Data kindly provided by Dr. Weis from Cheresh Lab, UCSD.

Anti-Eph receptor A4 antibody - ab54636 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab54636 Eph receptor A4 antibody at 1ug/ml.

Anti-Eph receptor A4 antibody [7D3D4] - ab70403 from Abcam

Host Mouse
Clonality Monoclonal
Clone 7D3D4
All lanes : Anti-Eph receptor A4 antibody [7D3D4] (ab70403) at 1/500 dilutionLane 1 : Molecular weight markersLane 2 : Truncated Trx-Eph receptor A4 recombinant proteinLane 3 : Truncated tagged-Eph receptor A4 (a777-986) recombinant protein

Anti-EPHA4 / EPH Receptor A4 Antibody (aa875-904) - LS-C100260 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Anti-EPHA4 / EPH Receptor A4 Antibody - LS-C150186 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-EPHA4 / EPH Receptor A4 Antibody (aa882-895) - LS-C147867 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-EPHA4 / EPH Receptor A4 Antibody (aa347) - LS-C190245 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-EPHA4 / EPH Receptor A4 Antibody (clone 7D3D4) - LS-C108865 from LifeSpan Bioscience

Prices $320.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7D3D4
Western blot using EphA4 mouse monoclonal antibody against truncated Trx-EphA4 recombinant protein (1) and truncated GST-EphA4(aa777-986) recombinant protein (2).

Anti-EPHA4 / EPH Receptor A4 Antibody (aa463-492, APC) - LS-C222446 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EPHA4 / EPH Receptor A4 Antibody (aa568-617) - LS-C151455 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
EPHA4 antibody Western Blot of Mouse Pancreas.

Anti-EPHA4 / EPH Receptor A4 Antibody - LS-C137038 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-EPHA4 / EPH Receptor A4 Antibody (aa463-492, Biotin) - LS-C222447 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EPHA4 / EPH Receptor A4 Antibody (aa463-492, FITC) - LS-C222448 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EPHA4 / EPH Receptor A4 Antibody (aa463-492, Azide-free, HRP) - LS-C222449 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EPHA4 / EPH Receptor A4 Antibody (aa463-492, PE) - LS-C222450 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EPHA4 / EPH Receptor A4 Antibody (C-Terminus, APC) - LS-C225348 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EPHA4 / EPH Receptor A4 Antibody (C-Terminus, AP) - LS-C225347 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EPHA4 / EPH Receptor A4 Antibody (C-Terminus, Biotin) - LS-C225350 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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