| Gene Symbol |
UBE2F
|
| Entrez Gene |
140739
|
| Alt Symbol |
NCE2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin-conjugating enzyme E2F (putative)
|
| Other Description |
NEDD8 carrier protein UBE2F|NEDD8 protein ligase UBE2F|NEDD8-conjugating enzyme 2|NEDD8-conjugating enzyme UBE2F
|
| Swissprots |
B4DZU2 Q969M7 B4DMK3 H9KVB9 B8ZZG2 B4DDT9 C9J212 A8K1Z8 B4DFI1
|
| Accessions |
AAY24220 CDM22106 EAW71128 EAW71129 EAW71130 EAW71131 EAW71132 EAW71133 EAW71134 Q969M7 AF310723 AAL26792 AK290063 BAF82752 AK293334 BAG56850 AK294107 BAG57442 AK297502 BAG59915 AK303094 BAG64204 BC010549 AAH10549 BC039435 BM470609 BM920749 BQ959565 BX421077 CN370973 CN370974 DA140546 DB118122 JF432618 ADZ15835 NM_001278305 NP_001265234 NM_001278306 NP_001265235 NM_001278307 NP_001265236 NM_001278308 NP_001265237 NM_080678 NP_542409 NR_103498 NR_103499 NR_103500
|
| Function |
Accepts the ubiquitin-like protein NEDD8 from the UBA3- NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5. {ECO:0000269|PubMed:19250909}.
|
| Tissue Specificity |
Widely expressed (at protein level). {ECO:0000269|PubMed:19250909}.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|