IMPDH2

Gene Symbol	IMPDH2
Entrez Gene	3615
Alt Symbol	IMPD2, IMPDH-II
Species	Human
Gene Type	protein-coding
Description	IMP (inosine 5'-monophosphate) dehydrogenase 2
Other Description	IMP (inosine monophosphate) dehydrogenase 2|IMP oxireductase 2|IMPD 2|IMPDH 2|inosine 5' phosphate dehydrogenase 2|inosine monophosphate dehydrogenase type II|inosine-5'-monophosphate dehydrogenase 2
Swissprots	P12268 Q6LEF3
Accessions	AAA36113 AAA67054 AAB70699 AAR84630 AAR84631 AAR84632 CBX53836 EAW64946 EAW64947 P12268 AK293397 BAH11500 AY545560 AAS50155 BC006124 AAH06124 BC009236 BC012840 AAH12840 BC015567 AAH15567 DQ893403 ABM84329 DQ896721 ABM87720 J04208 AAA36112 XM_006713128 XP_006713191 NM_000884 NP_000875
Function	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Subcellular Location	Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|PubMed:14766016}. Nucleus {ECO:0000255|HAMAP- Rule:MF_03156, ECO:0000269|PubMed:14766016}.
Tissue Specificity	IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
Top Pathways	Purine metabolism, Drug metabolism - other enzymes

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

IMPDH2 CRISPR/Cas9 KO Plasmid (h) - sc-410835 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IMPDH2 HDR Plasmid (h) - sc-410835-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IMPDH2 Double Nickase Plasmid (h) - sc-410835-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IMPDH2 Double Nickase Plasmid (h2) - sc-410835-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IMPDH2 CRISPR Activation Plasmid (h) - sc-410835-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IMPDH2 CRISPR Activation Plasmid (h2) - sc-410835-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IMPDH2 Lentiviral Activation Particles (h) - sc-410835-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IMPDH2 Lentiviral Activation Particles (h2) - sc-410835-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IMPDH2 siRNA (h) - sc-105573 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IMPDH2 shRNA Plasmid (h) - sc-105573-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IMPDH2 shRNA (h) Lentiviral Particles - sc-105573-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IMP Dehydrogenase 2/IMPDH2 RNAi - H00003615-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

IMP Dehydrogenase 2/IMPDH2 RNAi - H00003615-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU027541 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10660 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10660 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

IMPDH2 siRNA (Human) - CRH2421 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

IMPDH2 - MBS8222348 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human IMPDH2 (NM_000884.2) - SHH319361 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human IMPDH2(NM_000884.2) - SHL177204 from Creative biogene Category siRNA Species Reactivities Human

Human IMPDH2 siRNA - orb262923 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

IMPDH2 shRNA Plasmid (Human) - CHH2421 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

IMPDH2 miRNA 3'UTR clone - MiUTR1H-04938 from Creative biogene Species Reactivities Human

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