Ago2

Gene Symbol Ago2
Entrez Gene 239528
Alt Symbol 1110029L17Rik, 2310051F07Rik, AI225898, AL022874, AW546247, ENSMUSG00000072493, Eif2c2, Gerp95, Gm10365, mKIAA4215
Species Mouse
Gene Type protein-coding
Description argonaute RISC catalytic subunit 2
Other Description Piwi/Argonaute family protein meIF2C2|argonaute 2|argonaute RISC catalytic component 2|eukaryotic translation initiation factor 2C, 2|mAgo2|protein argonaute-2
Swissprots Q571J6 Q4VAB3 A1A563 Q8CJG0
Accessions AAN75580 EDL29413 EDL29414 Q8CJG0 AA058301 AA764090 AB081472 BAC15767 AI225898 AI225899 AI415636 AK003962 AK075904 AK142854 BAE25210 AK148725 AK220193 BAD90378 AL022874 AL118169 AW546247 BB765875 BC023279 BC024857 AAH24857 BC056639 AAH56639 BC064741 AAH64741 BC096465 AAH96465 BC128379 AAI28380 BC129922 AAI29923 BE650477 BG072618 BP767325 BY731067 BY732637 CA752432 CJ056675 DQ540998 DQ543695 DQ543696 DQ546154 DQ549215 DQ692047 DQ693350 DQ713527 NM_153178 NP_694818
Function Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to t
Subcellular Location Cytoplasm, P-body {ECO:0000255|HAMAP- Rule:MF_03031}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03031}. Note=Translational repression of mRNAs results in their recruitment to P-bodies. Translocation to the nucleus requires IMP8. {ECO:0000255|HAMAP-Rule:MF_03031}.
Tissue Specificity Ubiquitous expression in 9.5 day embryos with highest levels in forebrain, heart, limb buds, and branchial arches. {ECO:0000269|PubMed:15284456}.

Protein argonaute-2 (EIF2C2), Mouse, ELISA Kit - CSB-EL007520MO from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Protein argonaute-2, Eif2c2, Mouse, ELISA Kit - E11449m from ARP American Research Products

Category ELISA Kit
Prices $736.00
Sizes 96 t

eukaryotic translation initiation factor 2C, 2, ELISA Kit - MBS911752 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity The minimum detectable dose of mouse EIF2C2 is typically less than 7.8 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
Range 31.25 pg/ml -2000 pg/ml.

Mouse Protein argonaute-2(EIF2C2) ELISA kit - CSB-EL007520MO from Cusabio

Category ELISA Kit
Sensitivity 7.81pg/ml
Range 31.25 pg/ml-2000 pg/ml

Mouse AGO2 / EIF2C2 ELISA Kit (Sandwich ELISA) - LS-F16187 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity 31.2
Range 15.6-1000 pg/ml

Mouse EIF2C2 ELISA Kit - E052221 from Biobool

Category ELISA Kit
Sensitivity The minimum detectable dose of mouse EIF2C2 is typically less than 7.8 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the me

Mouse Ago2 ELISA Kit - E065053 from Biobool

Category ELISA Kit

AGO2 ELISA Kit (Mouse) (OKEH05654) - OKEH05654 from Aviva Systems Biology

Category ELISA Kit
Prices $500.00
Sizes 96 wells
Sensitivity 15.6 pg/mL
Range 31.2-2,000 pg/mL

argonaute-2, ELISA Kit - MBS288600 from MyBioSource

Category ELISA Kit
Prices $430.00, $570.00, $2,515.00, $4,520.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

AGO2 ELISA Kit (Mouse) (OKCA02435) - OKCA02435 from Aviva Systems Biology

Category ELISA Kit
Sensitivity 7.81 pg/mL
Range 31.25 - 2,000 pg/mL
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