FAS

Gene Symbol FAS
Entrez Gene 355
Alt Symbol ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6
Species Human
Gene Type protein-coding
Description Fas cell surface death receptor
Other Description APO-1 cell surface antigen|CD95 antigen|Delta Fas/APO-1/CD95|FAS 827dupA|FAS receptor variant 9|FASLG receptor|Fas (TNF receptor superfamily, member 6)|Fas AMA|TNF receptor superfamily member 6|apoptosis antigen 1|apoptosis-mediating surface antigen FAS|tumor necrosis factor receptor superfamily member 6|tumor necrosis factor receptor superfamily, member 6
Swissprots Q5T9P2 Q14295 P25445 Q6SSE9 Q5T9P3 Q14294 B6VNV4 A9UJX4 Q16652 Q14292 Q5T9P1 Q14293
Accessions AAC16236 AAC16237 AAR08906 AGR88646 AGR88647 AGR88648 BAA20850 CAC35539 CAC35540 CAC35541 CAD48928 CAD48929 CAD48930 CAD48931 CAD48932 EAW50147 EAW50148 EAW50149 EAW50150 EAW50151 EAW50152 P25445 AB209361 BAD92598 AK026195 AK290978 BAF83667 AK311164 AK311424 AK311499 AY495076 AAS76663 BC012479 AAH12479 BC065736 CR450307 CAG29303 DA759225 DB284727 DQ894675 ABM85601 EU481974 ACC91884 FJ200481 ACO54878 FJ373045 ACP28876 FJ373046 ACP28877 FM246457 FM246458 CAR92543 FM246459 CAR92544 HG503127 M67454 AAA63174 S78781 AAD14292 X63717 CAA45250 X83490 X83491 X83492 X83493 X89101 CAA61473 Z47993 CAA88031 Z47994 CAA88032 Z47995 CAA88033 Z66556 Z70519 CAA94430 Z70520 CAA94431 XM_006717819 XP_006717882 XM_011539764 XP_011538066 XM_011539765 XP_011538067 XM_011539766 XP_011538068 XM_011539767 XP_011538069 XR_945732 XR_945733 NM_000043 NP_000034 NM_152871 NP_690610 NM_152872 NP_690611 NR_028033 NR_028034 NR_028035 NR_028036 NM_152873 NM_152874 NM_152875 NM_152876 NM_152877
Function Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). {ECO:0000269|PubMed:19118384, ECO:0000269|PubMed:7533181}.
Subcellular Location Isoform 5: Secreted.
Tissue Specificity Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6. {ECO:0000269|PubMed:7575433}.
Top Pathways Proteoglycans in cancer, Herpes simplex infection, TNF signaling pathway, Influenza A, Non-alcoholic fatty liver disease (NAFLD)

Fas (4C3) Mouse mAb - 8023 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone 4C3
Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected (+) with a human Fas construct, using Fas (4C3) Mouse mAb.

Fas (C18C12) Rabbit mAb - 4233 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C18C12
Western blot analysis of extracts from COS cells, mock transfected or transfected with human Fas, and from ACHN and HT-1080 cell lines using Fas (C18C12) Rabbit mAb.

FAS (B-10) - sc-8009 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FAS (B-10): sc-8009. Western blot analysis of FAS expression in A-431 whole cell lysate.

FAS (C236) - sc-21730 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FAS (C236) PE: sc-21730 PE. FCM analysis of MCF7 cells. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-2866.

FAS (FL-335) - sc-7886 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FAS (FL-335): sc-7886. Western blot analysis of FAS expression in Jurkat whole cell lysate.

FAS (C-20) - sc-715 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FAS (C-20): sc-715. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human liver tumor. Note distinct membrane staining of hepatocytes.

FAS (G-9) - sc-74540 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FAS (G-9): sc-74540. Western blot analysis of FAS expression in MDA-MB-231 whole cell lysate.

FAS (N-18) - sc-714 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FAS (N-18): sc-714. Western blot analysis of FAS expression in A-431 (A), FAS treated Jurkat (B) and MDA-MB-231(C) whole cell lysates.

p-FAS (Tyr 291) - sc-130189 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-CD95 antibody [EOS9.1] - Low endotoxin, Azide free - ab185766 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone EOS9.1

Anti-Fas antibody - ab82419 from Abcam

Prices $398.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Fas antibody (ab82419) at 1/1000 dilutionLane 1 : Rat brain tissue extractLane 2 : Mouse brain tissue extractdeveloped using the ECL technique

Anti-Fas antibody - ab2437 from Abcam

Prices $379.00
Sizes 1 ml
Host Rabbit
Clonality Polyclonal
ab2437 at a 1:200 dilution staining Fas in Jurkat whole cell lysate ab2437 at a 1:200 dilution staining Fas in Jurkat whole cell lysate

Anti-Fas antibody - ab109913 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Human peripheral blood lymphocytes stained with ab109913 (red line). Human whole blood was processed using a modified protocol based on Chow et al, 2005 (PMID: 16080188). In brief, human whole blood was fixed in 4% formaldehyde (methanol-free) for 10 min at 22ºC. Red blood cells were then lyzed by the addition of Triton X-100 (final concentration - 0.1%) for 15 min at 37ºC. For experimentation, cells were treated with 50% methanol (-20ºC) for 15 min at 4ºC. Cells were then incubated with the antibody (ab109913, 0.01μg/1x106 cells) for 30 min at 4ºC. The secondary antibody used was Alexa Fluor&reg; 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 4ºC. Isotype control antibody (black line) was rabbit IgG (polyclonal) (0.01μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >30,000 total events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. Gating strategy - peri

Anti-Fas antibody - ab110021 from Abcam

Prices $384.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab110021, staining CD95 in Human small intestine tissue by immunohistochemistry.

Anti-Fas antibody - ab58394 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Fas antibody (ab58394) at 1/500 dilutionLane 1 : LOVO cell extract with no immunizing peptideLane 2 : LOVO cell extract with immunizing peptide

Anti-Fas antibody - ab62691 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab62691 at 1/500 - 1/1000 dilution staining CD95 in HeLa cells by Immunofluorescence, in the absence or presence of the immunising peptide

Anti-Fas antibody - ab175343 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Sandwich ELISA analysis of recombinant Human CD95 using ab175343 at a concentration of 0.5-2.0 μg/ml.

Anti-Fas antibody - ab103551 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Fas antibody (ab103551) at 1/500 dilution + A431 cell lysate at 50 µg

Anti-Fas antibody - ab1873 from Abcam

Prices $370.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal

Anti-Fas antibody - ab106839 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-Fas antibody (ab106839) at 0.1 µg/ml + MOLT4 cell lysate in RIPA buffer at 35 µg

Anti-Fas antibody - ab14022 from Abcam

Prices $359.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal

Anti-Fas antibody [4C3-G7-B7-H5] - ab106062 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4C3-G7-B7-H5
All lanes : Anti-Fas antibody [4C3-G7-B7-H5] (ab106062) at 1/1000 dilutionLane 1 : HepG2 whole cell lysateLane 2 : A431 whole cell lysateLane 3 : Jurkat whole cell lysateLysates/proteins at 40 µg per lane.

Anti-Fas antibody [4F8D6] - ab126836 from Abcam

Host Mouse
Clonality Monoclonal
Clone 4F8D6
ab126836, at 1/200 dilution, staining CD95 in HeLa cells by flow cytometry (green). Negative control (red).

Anti-Fas antibody [4F8H6] - ab126821 from Abcam

Host Mouse
Clonality Monoclonal
Clone 4F8H6
ab126821, with serial dilutions, against CD95 antigen, by ELISA.

Anti-Fas antibody [5F-7] - ab19454 from Abcam

Host Mouse
Clonality Monoclonal
Clone 5F-7
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