| Gene Symbol | FAS |
|---|---|
| Entrez Gene | 355 |
| Alt Symbol | ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 |
| Species | Human |
| Gene Type | protein-coding |
| Description | Fas cell surface death receptor |
| Other Description | APO-1 cell surface antigen|CD95 antigen|Delta Fas/APO-1/CD95|FAS 827dupA|FAS receptor variant 9|FASLG receptor|Fas (TNF receptor superfamily, member 6)|Fas AMA|TNF receptor superfamily member 6|apoptosis antigen 1|apoptosis-mediating surface antigen FAS|tumor necrosis factor receptor superfamily member 6|tumor necrosis factor receptor superfamily, member 6 |
| Swissprots | Q5T9P2 Q14295 P25445 Q6SSE9 Q5T9P3 Q14294 B6VNV4 A9UJX4 Q16652 Q14292 Q5T9P1 Q14293 |
| Accessions | AAC16236 AAC16237 AAR08906 AGR88646 AGR88647 AGR88648 BAA20850 CAC35539 CAC35540 CAC35541 CAD48928 CAD48929 CAD48930 CAD48931 CAD48932 EAW50147 EAW50148 EAW50149 EAW50150 EAW50151 EAW50152 P25445 AB209361 BAD92598 AK026195 AK290978 BAF83667 AK311164 AK311424 AK311499 AY495076 AAS76663 BC012479 AAH12479 BC065736 CR450307 CAG29303 DA759225 DB284727 DQ894675 ABM85601 EU481974 ACC91884 FJ200481 ACO54878 FJ373045 ACP28876 FJ373046 ACP28877 FM246457 FM246458 CAR92543 FM246459 CAR92544 HG503127 M67454 AAA63174 S78781 AAD14292 X63717 CAA45250 X83490 X83491 X83492 X83493 X89101 CAA61473 Z47993 CAA88031 Z47994 CAA88032 Z47995 CAA88033 Z66556 Z70519 CAA94430 Z70520 CAA94431 XM_006717819 XP_006717882 XM_011539764 XP_011538066 XM_011539765 XP_011538067 XM_011539766 XP_011538068 XM_011539767 XP_011538069 XR_945732 XR_945733 NM_000043 NP_000034 NM_152871 NP_690610 NM_152872 NP_690611 NR_028033 NR_028034 NR_028035 NR_028036 NM_152873 NM_152874 NM_152875 NM_152876 NM_152877 |
| Function | Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). {ECO:0000269|PubMed:19118384, ECO:0000269|PubMed:7533181}. |
| Subcellular Location | Isoform 5: Secreted. |
| Tissue Specificity | Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6. {ECO:0000269|PubMed:7575433}. |
| Top Pathways | Proteoglycans in cancer, Herpes simplex infection, TNF signaling pathway, Influenza A, Non-alcoholic fatty liver disease (NAFLD) |