| Gene Symbol | Exosc5 |
|---|---|
| Entrez Gene | 27998 |
| Alt Symbol | D7Wsu180e |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | exosome component 5 |
| Other Description | exosome complex component RRP46|exosome complex exonuclease RRP46|ribosomal RNA-processing protein 46 |
| Swissprots | Q9CRA8 Q8K1J2 |
| Accessions | EDL24246 EDL24247 Q9CRA8 AK006475 BAB24607 AK007372 BAB24993 AK053661 AK137780 AK143763 AK155228 BAE33136 AK189469 BB856072 BC034358 AAH34358 BC092393 BE854983 BY196593 BY198385 NM_138586 NP_613052 NR_104358 |
| Function | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways |
| Subcellular Location | Nucleus, nucleolus {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
| Top Pathways | RNA degradation |
EXOSC5 CRISPR/Cas9 KO Plasmid (m) - sc-424305 from Santa Cruz Biotechnology
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EXOSC5 HDR Plasmid (m) - sc-424305-HDR from Santa Cruz Biotechnology
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EXOSC5 Double Nickase Plasmid (m) - sc-424305-NIC from Santa Cruz Biotechnology
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EXOSC5 Double Nickase Plasmid (m2) - sc-424305-NIC-2 from Santa Cruz Biotechnology
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EXOSC5 CRISPR Activation Plasmid (m) - sc-424305-ACT from Santa Cruz Biotechnology
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EXOSC5 CRISPR Activation Plasmid (m2) - sc-424305-ACT-2 from Santa Cruz Biotechnology
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EXOSC5 Lentiviral Activation Particles (m) - sc-424305-LAC from Santa Cruz Biotechnology
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EXOSC5 Lentiviral Activation Particles (m2) - sc-424305-LAC-2 from Santa Cruz Biotechnology
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EXOSC5 siRNA (m) - sc-144978 from Santa Cruz Biotechnology
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EXOSC5 shRNA Plasmid (m) - sc-144978-SH from Santa Cruz Biotechnology
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EXOSC5 shRNA (m) Lentiviral Particles - sc-144978-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU030811 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN30847 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND30847 from Sigma-Aldrich
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EXOSC5 siRNA (Mouse) - CRM4965 from Cohesion Biosciences
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EXOSC5 - MBS8215334 from MyBioSource
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shRNA set against Mouse EXOSC5 (NM_138586.3) - SHH288133 from Creative biogene
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Mouse EXOSC5 siRNA - orb284441 from Biorbyt
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EXOSC5 shRNA Plasmid (Mouse) - CHM4965 from Cohesion Biosciences
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