| Gene Symbol |
Lrrc8d
|
| Entrez Gene |
305131
|
| Alt Symbol |
Lrrc5
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
leucine rich repeat containing 8 family, member D
|
| Other Description |
leucine rich repeat containing 5|leucine rich repeat containing 8D|leucine-rich repeat-containing 5|leucine-rich repeat-containing protein 5|leucine-rich repeat-containing protein 8D|volume-regulated anion channel subunit LRRC8D
|
| Swissprots |
Q5U308
|
| Accessions |
EDL99470 Q5U308 BC085783 AAH85783 XM_006250556 XP_006250618 NM_001008338 NP_001008339
|
| Function |
Component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8D constitutes a pore-forming subunit or whether it is closely associated with the pore (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Mainly localizes in the endoplasmic reticulum. {ECO:0000250}.
|