Tgfb1

Gene Symbol Tgfb1
Entrez Gene 100135628
Alt Symbol TGF-beta
Species Guinea Pig
Gene Type protein-coding
Description transforming growth factor, beta 1
Other Description TGF-beta-1|transforming growth factor beta-1|transforming growth factor-beta
Swissprots Q9R148 Q9QZB3 Q9Z1Y6
Accessions Q9Z1Y6 AF169347 AAD49347 AF191297 AAF02780 NM_001173023 NP_001166494
Function Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T- helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. {ECO:0000250|UniProtKB:P04202}.
Subcellular Location Secreted, extracellular space, extracellular matrix {ECO:0000250}.

TGFb1 Antibody - abx103670 from Abbexa

Host Rabbit
Clonality Polyclonal

Anti-Transforming Growth Factor Beta 1 (TGFb1) - 20-2298 from ARP American Research Products

Prices $359.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Transforming Growth Factor Beta 1, Polyclonal Antibody - MBS2026960 from MyBioSource

Prices $135.00, $160.00, $230.00, $310.00, $480.00, $1,155.00
Sizes 10 µg, 20 µg, 50 µg, 100 µg, 200 µg, 1 mg
Host Guinea Pig
Clonality Polyclonal
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