C1QBP

Gene Symbol	C1QBP
Entrez Gene	708
Alt Symbol	GC1QBP, HABP1, SF2p32, gC1Q-R, gC1qR, p32
Species	Human
Gene Type	protein-coding
Description	complement component 1, q subcomponent binding protein
Other Description	ASF/SF2-associated protein p32|C1q globular domain-binding protein|complement component 1 Q subcomponent-binding protein, mitochondrial|glycoprotein gC1qBP|hyaluronan-binding protein 1|mitochondrial matrix protein p32|p33|splicing factor SF2-associated protein
Swissprots	Q07021 Q2HXR8 Q9NNY8
Accessions	AAK26580 ABC79624 EAW90335 EAW90336 EAW90337 Q07021 AF275902 AAF78763 AJ297362 CAB95947 AK291516 BAF84205 BC000435 AAH00435 BC013731 AAH13731 BT019898 AAV38701 BT019899 AAV38702 DQ891331 ABM82257 DQ893366 ABM84292 DQ894514 ABM85440 DQ896683 ABM87682 L04636 AAA16315 X75913 CAA53512 NM_001212 NP_001203
Function	Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular "heads" of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK. Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-typ
Subcellular Location	Mitochondrion matrix. Nucleus. Cell membrane; Peripheral membrane protein; Extracellular side. Secreted. Cytoplasm. Nucleus, nucleolus. Note=Seems to be predominantly localized to mitochondria. Secreted by activated lymphocytes.
Tissue Specificity	Expressed on cell surface of peripheral blood cells (at protein level); Surface expression is reported for macrophages and monocyte-derived dendritic cells. {ECO:0000269|PubMed:12574814, ECO:0000269|PubMed:8662673}.
Top Pathways	Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

C1QBP CRISPR/Cas9 KO Plasmid (h) - sc-400911 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

C1QBP HDR Plasmid (h) - sc-400911-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

C1QBP Double Nickase Plasmid (h) - sc-400911-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

C1QBP Double Nickase Plasmid (h2) - sc-400911-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

C1QBP CRISPR Activation Plasmid (h) - sc-400911-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

C1QBP CRISPR Activation Plasmid (h2) - sc-400911-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

C1QBP Lentiviral Activation Particles (h) - sc-400911-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

C1QBP Lentiviral Activation Particles (h2) - sc-400911-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

C1QBP siRNA (h) - sc-42880 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

C1QBP shRNA Plasmid (h) - sc-42880-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

C1QBP shRNA (h) Lentiviral Particles - sc-42880-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

HABP1/C1QBP/GC1q R RNAi - H00000708-R01 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU108391 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN4684 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4684 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01342 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr01342

C1QBP siRNA (Human) - CRH0489 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

C1QBP - MBS8214064 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human C1QBP (NM_001212.3) - SHH250697 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human C1QBP(NM_001212.3) - SHG120553 from Creative biogene Category siRNA Species Reactivities Human

Human C1QBP siRNA - orb260991 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

C1QBP shRNA Plasmid (Human) - CHH0489 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

C1QBP miRNA 3'UTR clone - MiUTR1H-01284 from Creative biogene Species Reactivities Human

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