ADAM10

Gene Symbol	ADAM10
Entrez Gene	102
Alt Symbol	AD10, AD18, CD156c, HsT18717, MADM, RAK, kuz
Species	Human
Gene Type	protein-coding
Description	ADAM metallopeptidase domain 10
Other Description	CDw156|a disintegrin and metalloprotease domain 10|disintegrin and metalloproteinase domain-containing protein 10|kuzbanian protein homolog|mammalian disintegrin-metalloprotease
Swissprots	Q10742 B4DU28 Q92650 O14672
Accessions	CCQ43088 EAW77539 EAW77540 EAW77541 O14672 AA243020 AF009615 AAC51766 AK023460 AK300472 BAG62190 AY726599 BC055087 BC104659 BC126253 AAI26254 BC143935 BE327886 BE934813 BX372217 DA941750 Z48579 CAA88463 XM_005254117 XP_005254174 NM_001110 NP_001101
Function	Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth- like factor, ephrin-A2 and for constitutive and regulated alpha- secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I membrane protein. Note=Is localized in the plasma membrane but is predominantly expressed in the Golgi apparatus and in released membrane vesicles derived likely from the Golgi.
Tissue Specificity	Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver. {ECO:0000269|PubMed:11511685, ECO:0000269|PubMed:9016778}.
Top Pathways	Alzheimer's disease, Epithelial cell signaling in Helicobacter pylori infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ADAM10 peptide - ab41164 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

ADAM10 peptide - ab41165 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

ADAM10 peptide - ab41166 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

ADAM10 peptide - ab41167 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

ADAM10 peptide - ab94389 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

ADAM10 peptide - ab7868 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

Human ADAM10 peptide - ab93826 from Abcam Category Peptide

Human ADAM10 protein fragment - ab82822 from Abcam Category Protein Source E. coli Species Human

Human ADAM10 protein fragment - ab83118 from Abcam Category Protein Source E. coli Species Human

ADAM10 Antibody Blocking Peptide - LS-E29873 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ADAM10 Partial Recombinant Protein - H00000102-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

ADAM10 Blocking Peptide - NBP1-76973PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Recombinant Human ADAM10, CF - 936-AD-020 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Thr214-Glu672, with a C-terminal 10-His tag

ADAM10 Protein (OPPA02028) - OPPA02028 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

ADAM 10 (Western Blot Control) Protein (OPRB00251) - OPRB00251 from Aviva Systems Biology Category Protein Prices $249.00 Sizes 10 µg

ADAM 10 Protein (OPRB00252) - OPRB00252 from Aviva Systems Biology Category Protein Prices $249.00 Sizes 10 µg

ADAM10 Protein (OPRB00253) - OPRB00253 from Aviva Systems Biology Category Protein Prices $839.00 Sizes 100 µg

Human Disintegrin and Metalloproteinase Domain 10 protein - orb80900 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E.coli

CD156c Blocking Peptide - abx062210 from Abbexa Category Peptide Species Human, Mouse, Bovine, Pig

Human ADAM10 Protein - abx065056 from Abbexa Category Protein Source E.coli Species Human

CD156c / ADAM10 - H00000102-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CD156c / ADAM10 - H00000102-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CD156c / ADAM10 Control Peptide - AP30017CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

Recombinant Human ADAM10, HEK293 Lysate - 230-10038-100 from RayBiotech Category Protein Prices $154.00 Sizes 100 µg Source Human Embryonic Kidney 293 (HEK293) Cells Species Human

A Disintegrin and Metalloproteinase Domain 10, Human Recombinant - 228-10025-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

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