| Gene Symbol |
LEP
|
| Entrez Gene |
443534
|
| Alt Symbol |
ob
|
| Species |
Sheep
|
| Gene Type |
protein-coding
|
| Description |
leptin
|
| Other Description |
leptin (obesity homolog, mouse)
|
| Swissprots |
Q28603 P79212
|
| Accessions |
AAX15953 ABQ09501 ABQ09502 ABQ09503 ABQ09504 ABQ09505 AGL08817 AGL08818 AGL08819 AHG52886 AHG52887 AHG52888 AHG52889 AHG52890 AHG52891 AHG52892 AHG52893 AHG52894 AHG52895 AHG52896 AHI85736 AHI85737 AHI85738 AHI85739 AHI85740 AHY23913 AIM62157 AIM62158 AIZ94621 AIZ94622 AIZ94623 AIZ94624 AIZ94625 AIZ94626 CCE35540 Q28603 AF310264 FR688115 CBX02943 FR688116 CBX02944 FR688117 CBX02945 FR688118 CBX02946 U62123 AAB51033 U84247 AAB41786 XM_004008038 XP_004008087 XM_012131506 XP_011986896 XM_012131507 XP_011986897 XM_012131508 XP_011986898 XM_012131510 XP_011986900 XM_012177089 XP_012032479 XM_012177090 XP_012032480 XM_012177091 XP_012032481 XM_012177092 XP_012032482
|
| Function |
May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
|
| Subcellular Location |
Secreted {ECO:0000305}.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Adipocytokine signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AMPK signaling pathway
|
