| Gene Symbol |
TSG101
|
| Entrez Gene |
7251
|
| Alt Symbol |
TSG10, VPS23
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tumor susceptibility 101
|
| Other Description |
ESCRT-I complex subunit TSG101|tumor susceptibility gene 10|tumor susceptibility gene 101|tumor susceptibility gene 101 protein|tumor susceptibility protein
|
| Swissprots |
Q9BUM5 Q99816
|
| Accessions |
EAW68381 EAW68382 EAW68383 EAW68384 EAW68385 EAW68386 Q99816 AK130787 AU138453 AY207473 AAO59169 AY207474 AAO59170 BC002487 AAH02487 BP347883 CB528488 DQ892792 ABM83718 DQ896039 ABM87038 U82130 AAC52083 XM_005253108 XP_005253165 NM_006292 NP_006283
|
| Function |
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. {ECO:0000269|PubMed:11916981, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:21070952, ECO:0000269|PubMed:21757351}.
|
| Subcellular Location |
Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Late endosome membrane; Peripheral membrane protein. Note=Mainly cytoplasmic. Membrane-associated when active and soluble when inactive. Depending on the stage of the cell cycle, detected in the nucleus. Colocalized with CEP55 in the midbody during cytokinesis.
|
| Tissue Specificity |
Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas.
|
| Top Pathways |
Endocytosis
|
![Western Blot: TSG101 Overexpression Lysate (Adult Normal) [NBL1-17358] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TSG101.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1122_TSG101%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17358-img0002.jpg)