| Gene Symbol | St3gal2 |
|---|---|
| Entrez Gene | 20444 |
| Alt Symbol | AI429591, AW822065, ST3GalII, Siat5 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | ST3 beta-galactoside alpha-2,3-sialyltransferase 2 |
| Other Description | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2|SIAT4-B|ST3Gal II|ST3GalA.2|alpha 2,3-ST 2|beta-galactoside alpha-2,3-sialyltransferase 2|gal-NAc6S|gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase|sialyltransferase 4B|sialyltransferase 5 |
| Swissprots | Q11204 Q8BPL0 |
| Accessions | EDL11477 EDL11478 Q11204 AK029246 AK031052 AK034554 BAC28752 AK034863 BAC28859 AK037177 AK053827 BAC35543 AK131653 BAE20742 AK134937 BAE22346 BC015264 AAH15264 BC066064 AAH66064 BY582241 CJ174248 X76989 CAA54294 XM_006530786 XP_006530849 XM_006530787 XP_006530850 XM_006530788 XP_006530851 NM_009179 NP_033205 |
| Function | It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values. |
| Subcellular Location | Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane- bound form in trans cisternae of Golgi. Secreted into the body fluid. |
| Tissue Specificity | Strongly expressed in brain and liver and to a lesser extent in heart and kidney. Scarcely detectable in lung, pancreas, spleen and submaxillary gland. |
| Top Pathways | Mucin type O-Glycan biosynthesis, Glycosaminoglycan biosynthesis - keratan sulfate, Glycosphingolipid biosynthesis - globo series, Glycosphingolipid biosynthesis - ganglio series |
St3Gal-II CRISPR/Cas9 KO Plasmid (m) - sc-422937 from Santa Cruz Biotechnology
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St3Gal-II HDR Plasmid (m) - sc-422937-HDR from Santa Cruz Biotechnology
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St3Gal-II Double Nickase Plasmid (m) - sc-422937-NIC from Santa Cruz Biotechnology
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St3Gal-II Double Nickase Plasmid (m2) - sc-422937-NIC-2 from Santa Cruz Biotechnology
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St3Gal-II CRISPR Activation Plasmid (m) - sc-422937-ACT from Santa Cruz Biotechnology
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St3Gal-II CRISPR Activation Plasmid (m2) - sc-422937-ACT-2 from Santa Cruz Biotechnology
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St3Gal-II Lentiviral Activation Particles (m) - sc-422937-LAC from Santa Cruz Biotechnology
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St3Gal-II Lentiviral Activation Particles (m2) - sc-422937-LAC-2 from Santa Cruz Biotechnology
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St3Gal-II siRNA (m) - sc-153860 from Santa Cruz Biotechnology
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St3Gal-II shRNA Plasmid (m) - sc-153860-SH from Santa Cruz Biotechnology
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St3Gal-II shRNA (m) Lentiviral Particles - sc-153860-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU009821 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN42117 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND42117 from Sigma-Aldrich
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ST3GAL2 siRNA (Mouse) - CRM3719 from Cohesion Biosciences
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ST3GAL2 - MBS8234898 from MyBioSource
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shRNA set against Mouse ST3GAL2 (NM_009179.3) - SHH418816 from Creative biogene
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shRNA set against Mouse St3gal2(NM_009179.3) - SHL037902 from Creative biogene
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ST3GAL2 shRNA Plasmid (Mouse) - CHM3719 from Cohesion Biosciences
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ST3GAL2 miRNA 3'UTR clone - MiUTR1M-11272 from Creative biogene
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