DOCK7

Gene Symbol DOCK7
Entrez Gene 85440
Alt Symbol EIEE23, ZIR2
Species Human
Gene Type protein-coding
Description dedicator of cytokinesis 7
Other Description dedicator of cytokinesis protein 7
Swissprots Q5T1C0 Q96NG6 Q9C092 Q96NI0 Q96N67 Q45RE8 Q6ZV32 Q2PPY7 Q8TB82 Q45RE9 Q5T1B9 Q00M63
Accessions EAX06582 Q96N67 AB051558 BAB21862 AK022097 AK055296 AK055401 BAB70917 AK055493 BAB70933 AK055905 BAB71042 AK091479 BAG52372 AK125049 BAC86032 AK292640 BAF85329 AK299737 BAG61632 BC016392 AAH16392 BC018075 BC018076 BC041813 BC112387 AAI12388 BC172250 AAI72250 BG190976 BG205481 BG207092 BU567903 BU943181 BX094950 BX485492 DQ118679 AAZ38451 DQ118680 AAZ38452 DQ309763 ABC33725 DQ341187 ABC68221 DR002667 XM_005271292 XP_005271349 XM_011542326 XP_011540628 XM_011542327 XP_011540629 XM_011542328 XP_011540630 XM_011542329 XP_011540631 XM_011542330 XP_011540632 NM_001271999 NP_001258928 NM_001272000 NP_001258929 NM_001272001 NP_001258930 NM_001272002 NP_001258931 NM_033407 NP_212132
Function Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419}.
Subcellular Location Cell projection, axon {ECO:0000269|PubMed:16982419}. Note=Enriched in the developing axons of hippocampal neurons.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:11214970}.

Human DOCK7 protein fragment - ab132790 from Abcam

Category Protein
Source Wheat germ
Species Human
12.5% SDS-PAGE analysis of ab132790 stained with Coomassie Blue.

Human DOCK7 protein fragment - ab92221 from Abcam

Category Protein
Source E. coli
Species Human
The image shows an electrophoretic assay performed using an Agilent 5100 ALP. In some images colored control bands can be seen at 15 kDa (green) and/or 240 kDa (purple). The protein-specific band is blue.

DOCK7 - H00085440-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

DOCK7 - H00085440-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

DOCK7 fusion protein - ag3671 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Human DOCK7, His-tagged - DOCK7-28082TH from Creative Biomart

Category Protein
Source E. coli

Recombinant Human Dedicator of cytokinesis protein 7(DOCK7) ,partial - CSB-YP836266HU CSB-EP836266HU CSB-BP836266HU CSB-MP836266HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

DOCK7 Recombinant Protein - H00085440-P01 from Novus Biologicals

Category Protein
Prices $369.00
Sizes 10 µg
Species Human

DOCK7 Protein - NBP1-82894PEP from Novus Biologicals

Category Protein
Prices $209.00
Sizes 100 µl
Species Human

DOCK7 Peptide, Human - M34GP04479H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Dedicator of cytokinesis protein 7 (DOCK7), partial, Recombinant Protein - MBS1457442 from MyBioSource

Category Protein
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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