RAB5A

Gene Symbol RAB5A
Entrez Gene 5868
Alt Symbol RAB5
Species Human
Gene Type protein-coding
Description RAB5A, member RAS oncogene family
Other Description RAS-associated protein RAB5A|ras-related protein Rab-5A
Swissprots Q6FI44 P20339 B4DJA5
Accessions EAW64301 EAW64302 EAW64303 P20339 AF464088 AAO15677 AF498936 AAM21084 AK295992 BAG58767 AK309287 AK312618 BAG35504 AM392797 CAL37675 AM393001 CAL37879 BC001267 AAH01267 BC018288 AAH18288 BJ991078 CR536492 CAG38731 DA972638 DC330362 DQ891790 ABM82716 DQ894972 ABM85898 M28215 AAA60245 X13903 CAA32103 NM_001292048 NP_001278977 NM_004162 NP_004153
Function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. {ECO:0000269|PubMed:10818110, ECO:0000269|PubMed:14617813, ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:15378032, ECO:0000269|PubMed:16410077}.
Subcellular Location Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Early endosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Melanosome. Cytoplasmic vesicle {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Membrane. Cytoplasm, cytosol. Note=Enriched in stage I melanosomes. Alternates between membrane-bound and cytosolic forms.
Top Pathways Amyotrophic lateral sclerosis (ALS), Endocytosis, Vasopressin-regulated water reabsorption, Phagosome, Amoebiasis

Rab 5A CRISPR/Cas9 KO Plasmid (h) - sc-417949 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rab 5A HDR Plasmid (h) - sc-417949-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rab 5A Double Nickase Plasmid (h) - sc-417949-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rab 5A Double Nickase Plasmid (h2) - sc-417949-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rab 5A CRISPR Activation Plasmid (h) - sc-417949-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rab 5A CRISPR Activation Plasmid (h2) - sc-417949-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rab 5A Lentiviral Activation Particles (h) - sc-417949-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rab 5A Lentiviral Activation Particles (h2) - sc-417949-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rab 5A siRNA (h) - sc-36344 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Rab 5A shRNA Plasmid (h) - sc-36344-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Rab 5A shRNA (h) Lentiviral Particles - sc-36344-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Rab5a RNAi - H00005868-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU053901 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® esiRNA - EHU027641 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17859 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17859 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08975 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08975

RAB5A siRNA (Human) - CRH3958 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RAB5A - MBS8216994 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RAB5A (NM_004162.4) - SHH388488 from Creative biogene

Category siRNA
Species Reactivities Human

Human RAB5A siRNA - orb264460 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RAB5A shRNA Plasmid (Human) - CHH3958 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RAB5A miRNA 3'UTR clone - MiUTR3H-01986 from Creative biogene

Species Reactivities Human
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