TPPP

Gene Symbol TPPP
Entrez Gene 11076
Alt Symbol TPPP/p25, TPPP1, p24, p25, p25alpha
Species Human
Gene Type protein-coding
Description tubulin polymerization promoting protein
Other Description 25 kDa brain-specific protein|brain specific protein p25 alpha|glycogen synthase kinase 3 (GSK3) inhibitor p24|p25-alpha|tubulin polymerization-promoting protein
Swissprots O94811
Accessions EAW51015 EAW51016 O94811 AB017016 BAA36164 AI796918 AK054920 BAG51443 AK098392 AW955330 AY319261 AAQ96657 BC040496 AAH40496 BC131506 AAI31507 BC152382 AAI52383 BQ066916 BT020035 AAV38838 BU726600 DB478250 DB546894 XM_005248237 XP_005248294 NM_007030 NP_008961
Function May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown. {ECO:0000269|PubMed:17105200, ECO:0000269|PubMed:17693641, ECO:0000269|PubMed:18028908}.
Subcellular Location Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Localizes to glial Lewy bodies in the brains of individuals with synucleinopathies.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:10083737}.

TPPP (N-19) - sc-82065 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TPPP (N-19): sc-82065. Western blot analysis of TPPP expression in mouse brain (A), human cerebellum (B) and mouse cerebellum (C) tissue extracts.

TPPP (H-77) - sc-98687 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-Tubulin Polymerization Promoting Protein antibody - ab105033 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
ab105033 (3.8µg/ml) staining of paraffin embedded Human Cerebral Cortex following Steamed antigen retrieval with citrate buffer pH 6 and AP-staining shows cytoskeletal-like staining throughout the fibre network.

Anti-Tubulin Polymerization Promoting Protein antibody - ab67013 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-Tubulin Polymerization Promoting Protein antibody (ab67013) at 1/500 dilution + rat brain lysate at 25 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-Tubulin Polymerization Promoting Protein antibody [EPR3315] - ab119987 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3315
All lanes : Anti-Tubulin Polymerization Promoting Protein antibody [EPR3315] (ab119987) at 1/1000 dilutionLane 1 : Human fetal brain lysateLane 2 : SH-SY5Y cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-Tubulin Polymerization Promoting Protein antibody [EPR3316] - ab92305 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3316
Overlay histogram showing SH-SY5Y cells stained with ab92305 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab92305, 1/100 dilution) for 30 min at 22°C. The secondary antibody used was DyLight® 488 goat anti-rabbit IgG (H+L) (ab96899) at 1/500 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-TPPP Antibody (aa46-75, APC) - LS-C272030 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TPPP Antibody (aa46-75, AP) - LS-C272031 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TPPP Antibody (aa46-75, Biotin) - LS-C272032 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TPPP Antibody (aa46-75, FITC) - LS-C272033 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TPPP Antibody (aa46-75, Azide-free, HRP) - LS-C272035 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TPPP Antibody (aa46-75, PE) - LS-C272036 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TPPP Antibody (N-Terminus) - LS-C145510 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TPPP antibody LS-C145510 Western blot of Fetal Liver lysate. Antibody concentration 1 ug/ml.

Anti-TPPP Antibody (C-Terminus) - LS-C30616 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
TPPP antibody LS-C30616 Western blot of Frontal cortex lysate.

Anti-TPPP Antibody (aa8-210, Biotin) - LS-C300382 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TPPP Antibody (C-Terminus) - LS-C30615 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
TPPP antibody LS-C30615 Western blot of Brain lysate.

Anti-TPPP Antibody (aa8-210, FITC) - LS-C302319 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TPPP Antibody (aa46-75) - LS-C325894 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TPPP Antibody (aa47-75) - LS-C160143 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
TPPP Antibody western blot of NCI-H292 cell line lysates (35 ug/lane). The TPPP antibody detected the TPPP protein (arrow).

Anti-TPPP Antibody (aa8-210) - LS-C296844 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant TPPP.

Anti-TPPP Antibody (Internal, clone EPR3315) - LS-C105702 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3315
IHC of paraffin-embedded human astrocytoma using anti-TPPP antibody (LS-C105702).

Anti-TPPP Antibody (Internal, clone EPR3316) - LS-C105581 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3316
IHC of paraffin-embedded human brain tissue using anti-TPPP antibody (LS-C105581).

Anti-TPPP Antibody (aa21-35) IHC-plus™ - LS-B9213 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-TPPP antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

TPPP/p25 Antibody - NBP1-80962 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: TPPP/p25 Antibody [NBP1-80962] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-592

TPPP/p25 Antibody - NBP1-49833 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: TPPP/p25 Antibody [NBP1-49833] - (0.001ug/ml) staining of Mouse (A) and Rat (B) Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence
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