| Gene Symbol |
CELE_C32E8.10
|
| Entrez Gene |
171952
|
| Alt Symbol |
-
|
| Species |
C. elegans
|
| Gene Type |
protein-coding
|
| Description |
UNC-11
|
| Other Description |
-
|
| Swissprots |
Q95Q73 Q95Q72 Q9XZI9 Q9UA05 Q9XZI6 Q95Q75 Q9XZI8 Q95Q74 Q9UA04 Q9XZI7
|
| Accessions |
CCD66409 CCD66410 CCD66411 CCD66412 CCD66413 CCD66414 CCD66415 Q9XZI6 AF144257 AAD37365 AF144258 AAD37366 AF144259 AAD37367 NM_001025843 NP_001021014 NM_001025844 NP_001021015 NM_001025845 NP_001021016 NM_058826 NP_491227 NM_058827 NP_491228 NM_058828 NP_491229 NM_058829 NP_491230
|
| Function |
Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. Required for the efficient targeting of the synaptic vesicle protein synaptobrevin. {ECO:0000269|PubMed:10397769}.
|
| Subcellular Location |
Membrane, clathrin-coated pit {ECO:0000269|PubMed:10397769}. Golgi apparatus {ECO:0000269|PubMed:10397769}. Cytoplasmic vesicle, clathrin- coated vesicle {ECO:0000269|PubMed:10397769}. Note=Colocalized with clathrin in the Golgi area.
|
| Tissue Specificity |
High levels in the nervous system and at lower levels in other tissues. In neurons, enriched at presynaptic terminals and is also present in cell bodies. {ECO:0000269|PubMed:10397769}.
|