| Gene Symbol |
CALD1
|
| Entrez Gene |
373965
|
| Alt Symbol |
-
|
| Species |
Chicken
|
| Gene Type |
protein-coding
|
| Description |
caldesmon 1
|
| Other Description |
CDM|caldesmon
|
| Swissprots |
Q90761 Q03698 Q92018 Q90756 P12957 Q99230
|
| Accessions |
BAA04538 BAA04539 BAA04540 P12957 CR389525 CR523229 CR523598 J04968 AAA49067 M26684 AAA48811 M28417 AAA48810 M59762 AAA48649 M60620 AAA48936 NM_204158 NP_989489
|
| Function |
Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, myofibril {ECO:0000250}. Note=On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle). {ECO:0000250}.
|
| Tissue Specificity |
High-molecular-weight caldesmon (h-caldesmon) is predominantly expressed in smooth muscles, whereas low- molecular-weight caldesmon (l-caldesmon) is widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart.
|
| Top Pathways |
Vascular smooth muscle contraction
|
