MET

Gene Symbol MET
Entrez Gene 4233
Alt Symbol AUTS9, HGFR, RCCP2, c-Met
Species Human
Gene Type protein-coding
Description MET proto-oncogene, receptor tyrosine kinase
Other Description HGF receptor|HGF/SF receptor|SF receptor|hepatocyte growth factor receptor|met proto-oncogene tyrosine kinase|proto-oncogene c-Met|scatter factor receptor|tyrosine-protein kinase Met
Swissprots O60366 P08581 Q12875 E7EQ94 A1L467 B5A932 Q9UDX7 Q9UPL8
Accessions AAA59585 AAA59589 AAB54047 AAC60383 AAF66137 EAL24359 EAW83507 EAW83508 EAW83509 EAW83510 EAW83511 P08581 AA278232 AB209898 BAD93135 AF075090 AI630755 AK025784 AK296974 BAG59517 AK298552 BAG60748 AK309532 BC016592 BC027979 AAH27979 BC127890 AAI27891 BC130420 AAI30421 BX648782 DQ656040 EU176015 ABX52004 EU826567 ACF47603 EU826568 ACF47604 EU826569 ACF47605 EU826570 ACF47606 EU826571 ACF47607 EU826572 ACF47608 EU826573 ACF47609 EU826574 ACF47610 EU826575 ACF47611 EU826576 ACF47612 EU826577 ACF47613 EU826578 ACF47614 EU826579 ACF47615 EU826580 ACF47616 EU826581 ACF47617 J02958 AAA59591 M35074 AAA59590 U11813 AAA68513 X54559 CAB56793 XM_006715990 XP_006716053 XM_006715991 XP_006716054 XM_011516223 XP_011514525 NM_000245 NP_000236 NM_001127500 NP_001120972
Function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, parti
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Expressed in normal hepatocytes as well as in epithelial cells lining the stomach, the small and the large intestine. Found also in basal keratinocytes of esophagus and skin. High levels are found in liver, gastrointestinal tract, thyroid and kidney. Also present in the brain. {ECO:0000269|PubMed:1719465, ECO:0000269|PubMed:1917129}.
Top Pathways Bacterial invasion of epithelial cells, MicroRNAs in cancer, Central carbon metabolism in cancer, Rap1 signaling pathway, PI3K-Akt signaling pathway

Phospho-Met (Tyr1234/1235) (D26) XP ® Rabbit mAb (Alexa Fluor ® 594 Conjugate) - 8564 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D26
Confocal immunofluorescent analysis of MKN-45 cells, untreated (left) or treated with Su11274 (right), using Phospho-Met (Tyr1234/1235) (D26) XP® Rabbit mAb (Alexa Fluor® 594 Conjugate) (red). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye).

Phospho-Met (Tyr1234/1235) (D26) XP ® Rabbit mAb (Biotinylated) - 4033 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D26
Western blot analysis of extracts from A-431 cells, untreated or treated with hepatocyte growth factor (HGF), using Phospho-Met (Tyr1234/1235) (D26) XP ® Rabbit mAb (Biotinylated) and developed using Streptavidin-HRP #3999.

Phospho-Met (Tyr1234/1235) (D26) XP ® Rabbit mAb (PE Conjugate) - 12468 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D26
Flow cytometric analysis of MKN-45 cells, untreated (green) or SU11274-treated (5 μM, 3 hr; blue) using Phospho-Met (Tyr1234/Tyr1235) (D26) XP ® Rabbit mAb (PE Conjugate).

Met (D1C2) XP ® Rabbit mAb (Biotinylated) - 8041 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1C2
Western blot analysis of extracts from SK-BR-3 (Met-) and HT-29 (Met+) cells using Met (D1C2) XP ® Rabbit mAb (Biotinylated).

Met (D1C2) XP ® Rabbit mAb (Alexa Fluor ® 488 Conjugate) - 8494 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D1C2
Confocal immunofluorescent analysis of HT-29 (left) and T-47D (right) cells using Met (D1C2) XP ® Rabbit mAb (Alexa Fluor ® 488 Conjugate) (green). Actin filaments were labeled with DY-554 phalloidin (red). Blue pseudocolor = DRAQ5 ® #4084 (fluorescent DNA dye).

Met (L41G3) Mouse mAb (Biotinylated) - 5086 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone L41G3
Western blot analysis of extracts from MKN-45 and HCC827 cells using Met (L41G3) Mouse mAb (Biotinylated) and detected using Streptavidin-HRP #3999.

Phospho-Met (Tyr1234/1235) (D26) XP ® Rabbit mAb - 3077 from Cell Signaling Technology

Prices $119.00, $318.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D26
Western blot analysis of cell extracts from HeLa cells, untreated or stimulated with HGF, using Phospho-Met (Tyr1234/1235) (D26) XP ® Rabbit mAb (upper) and Met (25H2) Mouse mAb #3127 (lower).

Phospho-Met (Tyr1349) Antibody - 3121 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from mIMCD-3 cells, untreated or HGF-stimulated (40 ng/ml for 2 minutes), using Phospho-Met (Tyr1349) Antibody (upper) or Met antibody (lower).

Phospho-Met (Tyr1234/1235) (3D7) Rabbit mAb - 3129 from Cell Signaling Technology

Prices $307.00, $719.00
Sizes 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Monoclonal
Clone 3D7
Western blot analysis of extracts of H4IIE cells untreated or treated with HGF, using Phospho-Met (Tyr1234/1235) (3D7) Rabbit mAb (upper) or Met (25H2) Mouse mAb #3127 (lower).

Phospho-Met (Tyr1234/1235) Antibody - 3126 from Cell Signaling Technology

Prices $287.00, $678.00
Sizes 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from mIMCD-3, A431 and Vero cells, untreated or HGF-stimulated (40 ng/ml for 5 minutes), using Phospho-Met (Tyr1234/1235) Antibody.

Phospho-Met (Tyr1349) (130H2) Rabbit mAb - 3133 from Cell Signaling Technology

Prices $109.00, $307.00, $719.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Monoclonal
Clone 130H2
Western blot analysis of cell lysates of H4IIE cells untreated or treated with HGF, using Phospho-Met (Tyr1349) (130H2) Rabbit mAb (upper), or Met (25H2) Mouse mAb #3127 (lower).

Phospho-Met (Tyr1003) (13D11) Rabbit mAb - 3135 from Cell Signaling Technology

Prices $109.00, $307.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 13D11
Western blot analysis of extracts from A431 cells, untreated or HGF-treated using Phospho-Met (Tyr1003) (13D11) Rabbit mAb (upper and middle) and Met (25H2) Mouse mAb #3127 (lower). The middle blot was treated with CIP phosphatase before antibody probing.

Met (D1C2) XP ® Rabbit mAb - 8198 from Cell Signaling Technology

Prices $109.00, $282.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1C2
Western blot analysis of extracts from HT-29 (Met+), SK-BR-3 (Met-), and T-47D (Met-) cells using Met (D1C2) XP ® Rabbit mAb (upper) or β-Actin Antibody #4967 (lower).

Met (L6E7) Mouse mAb - 8741 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (200 tests)
Host Mouse
Clonality Monoclonal
Clone L6E7
Confocal immunofluorescent analysis of HCT 116 (left) and T-47D (right) cells using MET (L6E7) Mouse mAb (green). Actin filaments were labeled with DY-554 phalloidin (red). Blue pseudocolor = DRAQ5 ® #4084 (fluorescent DNA dye).

Met (25H2) Mouse mAb - 3127 from Cell Signaling Technology

Prices $246.00, $596.00
Sizes 100 µl (10 western blots), 300 µl (30 western blots)
Host Mouse
Clonality Monoclonal
Clone 25H2
Western blot analysis of extracts from various cell lines: mIMCD3 (lane 1), Vero (lane 2), 293 (HGF stimulated; lane 3) 293 (starved; lane 4) and C6 (lane 5), using Met (25H2) Mouse mAb.

Met Antibody - 4560 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using Met Antibody.

Met (L41G3) Mouse mAb - 3148 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone L41G3
Western blot analysis of extracts from A459 and COS cells using Met (L41G3) Mouse mAb. This antibody detects pro-c-Met of 175 kDa, mature c-Met β subunit of 145 kDa and a 125 kDa under-glycosylated c-Met protein.

Met (11C4) Mouse mAb (Flow Specific) - 5631 from Cell Signaling Technology

Prices $246.00
Sizes 200 µl (100 tests)
Host Mouse
Clonality Monoclonal
Clone 11C4
Flow cytometric analysis of live Ramos cells (red) and live MKN-45 cells (blue) using Met (11C4) Mouse mAb (Flow Specific).

Met (D-4) - sc-514148 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Met (D-4): sc-514148. Western blot analysis of Met expression in HeLa whole cell lysate.

Met (H-10) - sc-514149 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Met (H-10): sc-514149. Western blot analysis of Met expression in HeLa whole cell lysate.

Met (C-12) - sc-10 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Met (C-12): sc-10. Western blot analysis of Met expression in A-431 whole cell lysate.

Met (C-28) - sc-161 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Met (C-28): sc-161. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing membrane and cytoplasmic staining.

Met (H-190) - sc-8307 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Met (H-190): sc-8307. Western blot analysis of Met expression in LADMAC whole cell lysate.

Met (N-17) - sc-46395 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Met (N-17): sc-46395. Immunoperoxidase staining of formalin fixed, paraffin-embedded human small intestine tissue showing cytoplasmic staining of glandular cells.

Met (SP260) - sc-162 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Met (SP260): sc-162. Immunofluorescence staining of methanol-fixed A-431 cells showing membrane localization.
Search more