SPHK1

Gene Symbol	SPHK1
Entrez Gene	8877
Alt Symbol	SPHK
Species	Human
Gene Type	protein-coding
Description	sphingosine kinase 1
Other Description	SK 1|SPK 1
Swissprots	Q9NYA1 Q9NY70 Q9HD92 Q96GK1 Q8N632 Q9NYL3
Accessions	AAP35060 CAE90363 CAE90969 EAW89388 EAW89389 EAW89390 EAW89391 EAW89392 EAW89393 EAW89394 Q9NYA1 AF200328 AAG01980 AF238083 AAF73423 AF266756 AAF73470 AJ245504 CAB92131 AK022402 BAB14028 AK023393 BAB14558 AK095578 AK122781 BAG53725 AK225250 AK225258 AK292294 BAF84983 AK292614 BAF85303 BC004112 AAH04112 BC008040 AAH08040 BC009419 AAH09419 BC014439 AAH14439 BC030553 AAH30553 BP304783 DC384776 XM_005257766 XP_005257823 XM_011525439 XP_011523741 NM_001142601 NP_001136073 NM_001142602 NP_001136074 NM_021972 NP_068807 NM_182965 NP_892010
Function	Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. {ECO:0000269|PubMed:20577214, ECO:0000269|PubMed:23602659}.
Subcellular Location	Cytoplasm. Nucleus. Cell membrane. Note=Translocated from the cytoplasm to the plasma membrane in a CIB1-dependent manner.
Tissue Specificity	Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle. {ECO:0000269|PubMed:10802064}.
Top Pathways	VEGF signaling pathway, Calcium signaling pathway, Fc gamma R-mediated phagocytosis, Tuberculosis, Sphingolipid signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human SPHK1 full length protein - ab125662 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Human SPHK1 full length protein - ab152931 from Abcam Category Protein Source Wheat germ Species Human

Human SPHK1 peptide - ab16634 from Abcam Category Peptide

Human SPHK1 peptide - ab22795 from Abcam Category Peptide Species Human

Human SPHK1 protein fragment - ab152932 from Abcam Category Protein Source Wheat germ Species Human

Mouse SPHK1 full length protein - ab61642 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Mouse

SPHK / SPHK1 Blocking Peptide - LS-E25278 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SPHK / SPHK1 Antibody Blocking Peptide - LS-E28688 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

SPHK / SPHK1 Antibody Blocking Peptide - LS-E28687 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

SPHK / SPHK1 Antibody Blocking Peptide - LS-E28686 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

SPHK / SPHK1 Antibody Blocking Peptide - LS-E8786 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SPHK / SPHK1 Antibody Blocking Peptide - LS-E8785 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SPHK / SPHK1 Antibody Blocking Peptide - LS-E8787 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SPHK / SPHK1 Antibody Blocking Peptide - LS-E8788 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SPHK / SPHK1 Antibody Blocking Peptide - LS-E23145 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SPHK / SPHK1 Antibody Blocking Peptide - LS-E26654 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Sphingosine Kinase 1/SPHK1 Protein - H00008877-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Sphingosine Kinase 1/SPHK1 Protein - H00008877-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Sphingosine Kinase 1/SPHK1 Peptide - P2410 from Novus Biologicals Category Peptide Species Human

Sphingosine Kinase 1/SPHK1 Peptide - P2409 from Novus Biologicals Category Peptide Species Human

SPHK1-Antibody-N-term-P74-Blocking-Peptide - BP7237d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SPHK1-Antibody-Center-Blocking-Peptide - BP7237c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SPHK1-Antibody-C-term-R414-Blocking-Peptide - BP7237b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SPHK1-Antibody-N-term-Blocking-Peptide - BP7237a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SPHK1 (C-term.) blocking peptide - GTX89977-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

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