BDNF

Gene Symbol BDNF
Entrez Gene 627
Alt Symbol ANON2, BULN2
Species Human
Gene Type protein-coding
Description brain-derived neurotrophic factor
Other Description abrineurin|neurotrophin
Swissprots D3DQZ2 A7LA92 Q598Q1 A7LA85 Q9BYY7 Q6YNR3 Q9UC24 P23560 Q6YNR2 Q6DN19
Accessions AAA51820 AAA96140 AAG47514 AAO15434 EAW68274 EAW68275 EAW68276 EAW68277 EAW68278 EAW68279 P23560 AB038670 BAB55545 AB038671 BAB55546 AB038672 BAB55547 AB038673 BAB55548 AB038674 BAB55549 AF400438 AAK92487 AK289763 BAF82452 AK289853 BAF82542 AY054392 AAL23557 AY054393 AAL23558 AY054394 AAL23559 AY054395 AAL23560 AY054396 AAL23561 AY054397 AAL23562 AY054398 AAL23563 AY054399 AAL23564 AY054400 AAL23565 AY054406 AAL23571 AY442188 AAR14686 AY656701 AAT74399 BC029795 AAH29795 CX751420 DQ250642 ABB51155 DQ890811 ABM81737 DQ893966 ABM84892 EF674517 ABS29021 EF674518 ABS29022 EF674519 ABS29023 EF674520 ABS29024 EF674521 ABS29025 EF689009 ABS32249 EF689010 ABS32250 EF689011 ABS32251 EF689012 ABS32252 EF689013 ABS32253 EF689014 ABS32254 EF689015 ABS32255 EF689016 ABS32256 EF689017 ABS32257 EF689018 ABS32258 EF689019 ABS32259 EF689020 ABS32260 EF689021 ABS32261 KC855559 AGR50950 KP229412 AKB90516 M61176 AAA69805 X60201 CAA42761 X91251 CAA62632 XM_011520280 XP_011518582 NM_001143805 NP_001137277 NM_001143806 NP_001137278 NM_001143807 NP_001137279 NM_001143808 NP_001137280 NM_001143809 NP_001137281 NM_001143810 NP_001137282 NM_001143811 NP_001137283 NM_001143812 NP_001137284 NM_001143813 NP_001137285 NM_001143814 NP_001137286 NM_001143816 NP_001137288 NM_001709 NP_001700 NM_170731 NP_733927 NM_170732 NP_733928 NM_170733 NP_733929 NM_170734 NP_733930 NM_170735 NP_733931 NM_001143815
Function During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. {ECO:0000269|PubMed:12553913}.
Subcellular Location Secreted.
Tissue Specificity Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta. {ECO:0000269|PubMed:17629449}.
Top Pathways Huntington's disease, MAPK signaling pathway, Neurotrophin signaling pathway, Cocaine addiction, Alcoholism

BDNF (N-20) - sc-546 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
BDNF (N-20): sc-546. Western blot analysis of BDNF expression in SH-SY5Y (A) and U-87 MG (B) whole cell lysates.

BDNF (H-117) - sc-20981 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
BDNF (H-117): sc-20981. Immunoperoxidase staining of formalin fixed, paraffin-embedded human skeletal muscle tissue showing cytoplasmic staining of myocytes at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

BDNF (P-14) - sc-33905 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
BDNF (P-14): sc-33905. Immunoperoxidase staining of formalin fixed, paraffin-embedded human hippocampus tissue showing cytoplasmic staining of neuronal cells and glial cells.

BDNF (K-14) - sc-33904 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
BDNF (K-14): sc-33904. Western blot analysis of BDNF expression in mouse brain (A) and rat hippocampus (B) tissue extracts.

pro BDNF (9C1) - sc-65513 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

pro BDNF (5H8) - sc-65514 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Anti-BDNF antibody - ab6201 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-BDNF antibody (ab6201)Lane 1 : Purified rHBNDF at 0.05 µgLane 2 : Mouse brian lysate at 15 µgObserved band size : 14,28 kDa (why is the actual band size different from the predicted?)

Anti-BDNF antibody - ab72439 from Abcam

Prices $382.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal
ab72439 staining BDNF in Mouse ovarian tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was blocked with 10% serum in 0.1% Triton X-100; antigen retrieval was by heat mediation in a citrate buffer (pH 6.0). Samples were incubated with primary antibody (1/100) overnight at 4°C. A HRP-conjugated Horse anti-rabbit IgG polyclonal (1/2000) was used as the secondary antibody.

Anti-BDNF antibody - ab75040 from Abcam

Prices $392.00
Sizes 500 µg
Host Sheep
Clonality Polyclonal
ab75040 staining cultured rat DRG neurons by ICC/IF. The cultured neurons were fixed with formaldehyde and blocked with 10% donkey serum for 1 hour  at 24°C. The cultured neurons were then stained with ab75040 at 1/100 in 0.3% TritonX with 0.1x PBS and 10% donkey serum for 24h at 4°C. An Alexa Fluro 488 donkey anti-sheep polyclonal antibody at 1/1000 was used as the secondary antibody. Beta II tubulin  (which stains the axons) can be observed in red (Alexa fluro 568 secondary). BDNF is observable in the DRG neuron's growth cones.See Abreview

Anti-BDNF antibody - ab46176 from Abcam

Host Rabbit
Clonality Polyclonal
ICC/IF image of ab46176 stained SKNSH cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab46176 at 1/200 dilution overnight at +4°C. The secondary antibody (green) was DyLight® 488 Goat anti-Rabbit IgG (H+L) (ab96899) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-BDNF antibody - ab101747 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab101747 stained SKNSH cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab101747 at 1/200 dilution overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-BDNF antibody - ab101748 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-BDNF antibody - ab101752 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-BDNF antibody - ab24491 from Abcam

Prices $373.00
Sizes 100 µl
Host Sheep
Clonality Polyclonal

Anti-BDNF antibody - ab101751 from Abcam

Host Goat
Clonality Polyclonal

Anti-BDNF antibody - ab27932 from Abcam

Prices $372.00
Sizes 100 µg
Host Chicken
Clonality Polyclonal

Anti-BDNF antibody - ab88901 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-BDNF antibody (ab88901) at 1/500 dilution + cell lysate from NIH/3T3 at 50 µg

Anti-BDNF antibody - ab6200 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-BDNF antibody - ab9793 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-BDNF antibody - ab28952 from Abcam

Prices $370.00
Sizes 100 µg
Host Chicken
Clonality Polyclonal

Anti-BDNF antibody [35928.11] - ab10505 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 35928.11

Anti-BDNF antibody [3D9C5] - ab181748 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3D9C5
Immunofluorescent analysis of HeLa cells labeling BDNF with ab181748 at 1/200 (green). Blue: DRAQ5 fluorescent DNA dye.

Anti-BDNF antibody [ANT-128] - ab41180 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone ANT-128

Anti-BDNF antibody [EP1293] - ab108383 from Abcam

Host Rabbit
Clonality Monoclonal
Clone EP1293
All lanes : Anti-BDNF antibody [EP1293] (ab108383) at 1/1000 dilutionLane 1 : C6 cell lysate at 10 µgLane 2 : Fetal brain lysate at 10 µgLane 3 : Human hippocampus lysate at 10 µgLane 4 : Recombinant BDNF protein at 10 ng

Anti-BDNF antibody [EPR1292] - ab108319 from Abcam

Host Rabbit
Clonality Monoclonal
Clone EPR1292
Immunohistochemical analysis of paraffin-embedded Human brain tissue using ab108319 at 1/100
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