PLB1

Gene Symbol PLB1
Entrez Gene 100009309
Alt Symbol PHLPB
Species Rabbit
Gene Type protein-coding
Description phospholipase B1
Other Description PLB/LIP|phospholipase AdRab-B|phospholipase B|phospholipase B/lipase|phospholipase B1, membrane-associated
Swissprots Q05017
Accessions Q05017 Z12841 CAA78303 NM_001101708 NP_001095178
Function Membrane-associated phospholipase. Exhibits a calcium- independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Can convert phosphatidylcholine to fatty acids and glycerophosphocholine. Could be involved in uptake of dietary lipids, possibly including long chain retinyl esters. {ECO:0000269|PubMed:8509424}.
Subcellular Location Apical cell membrane {ECO:0000250}; Single- pass type I membrane protein {ECO:0000250}. Note=Present in the intestinal brush border membranes.
Tissue Specificity Intestine. {ECO:0000269|PubMed:8509424}.
Top Pathways Vitamin digestion and absorption, Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, Linoleic acid metabolism