| Gene Symbol |
MIF
|
| Entrez Gene |
780466
|
| Alt Symbol |
-
|
| Species |
Sheep
|
| Gene Type |
protein-coding
|
| Description |
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
|
| Other Description |
L-dopachrome isomerase|L-dopachrome tautomerase|Phenylpyruvate tautomerase|macrophage migration inhibitory factor
|
| Swissprots |
Q1ZZU7
|
| Accessions |
Q1ZZU7 DQ152976 ABB02309 DQ414692 ABD67167 GAAI01000482 NM_001078655 NP_001072123
|
| Function |
Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti- inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens (By similarity). {ECO:0000250}.
|
| Top Pathways |
Phenylalanine metabolism, Tyrosine metabolism
|