| Gene Symbol |
IL1A
|
| Entrez Gene |
100064969
|
| Alt Symbol |
-
|
| Species |
Horse
|
| Gene Type |
protein-coding
|
| Description |
interleukin 1, alpha
|
| Other Description |
IL-1 alpha|interleukin-1 alpha
|
| Swissprots |
Q28385 O77743
|
| Accessions |
Q28385 D42146 BAA07717 U92480 AAC39255 NM_001082500 NP_001075969
|
| Function |
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
|
| Top Pathways |
MAPK signaling pathway, Apoptosis, Inflammatory bowel disease (IBD), Non-alcoholic fatty liver disease (NAFLD), Hematopoietic cell lineage
|