| Gene Symbol |
SHH
|
| Entrez Gene |
395615
|
| Alt Symbol |
-
|
| Species |
Chicken
|
| Gene Type |
protein-coding
|
| Description |
sonic hedgehog
|
| Other Description |
sonic hedgehog homolog|sonic hedgehog protein
|
| Swissprots |
Q91035
|
| Accessions |
CAJ18804 Q91035 L28099 AAA72428 NM_204821 NP_990152
|
| Function |
Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. {ECO:0000269|PubMed:7736596}.
|
| Subcellular Location |
Sonic hedgehog protein C-product: Secreted, extracellular space {ECO:0000250}. Note=The C-terminal peptide diffuses from the cell. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in the posterior limb bud mesenchyme, the Hensen node, the notochord, and the floor plate of the neural tube.
|
| Top Pathways |
Hedgehog signaling pathway
|