| Gene Symbol | PARP3 |
|---|---|
| Entrez Gene | 10039 |
| Alt Symbol | ADPRT3, ADPRTL2, ADPRTL3, ARTD3, IRT1, PADPRT-3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | poly (ADP-ribose) polymerase family, member 3 |
| Other Description | ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 2|ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 3|ADP-ribosyltransferase diphtheria toxin-like 3|ADPRT-3|NAD(+) ADP-ribosyltransferase 3|NAD+ ADP-ribosyltransferase 3|poly [ADP-ribose] polymerase 3|poly(ADP-ribose) synthetase-3|poly[ADP-ribose] synthase 3|poly[ADP-ribose] synthetase 3 |
| Swissprots | Q9Y6F1 Q9UG81 Q96CG2 Q8NER9 |
| Accessions | CAC07443 CAC07444 EAW65160 EAW65161 EAW65162 EAW65163 Q9Y6F1 AB208803 BAD92040 AF083068 AAD29855 AI088919 AL050034 CAB43246 AY126341 AAM95460 BC014260 AAH14260 BF375394 BG818516 BI554046 BU632340 CA309713 CA394313 JF432226 ADZ15443 Y16836 CAC79988 XM_005264779 XP_005264836 XM_011533257 XP_011531559 XM_011533258 XP_011531560 NM_001003931 NP_001003931 NM_005485 NP_005476 NM_001003935 |
| Function | Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing. {ECO:0000269|PubMed:16924674}. |
| Subcellular Location | Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Core component of the centrosome. Preferentially localized to the daughter centriole throughout the cell cycle. According to PubMed:16924674, it is almost exclusively localized in the nucleus and appears in numerous small foci and a small number of larger foci whereas a centrosomal location has not been detected. |
| Tissue Specificity | Widely expressed; the highest levels are in the kidney, skeletal muscle, liver, heart and spleen; also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus. |
| Top Pathways | Base excision repair |