PARP3

Gene Symbol	PARP3
Entrez Gene	10039
Alt Symbol	ADPRT3, ADPRTL2, ADPRTL3, ARTD3, IRT1, PADPRT-3
Species	Human
Gene Type	protein-coding
Description	poly (ADP-ribose) polymerase family, member 3
Other Description	ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 2|ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 3|ADP-ribosyltransferase diphtheria toxin-like 3|ADPRT-3|NAD(+) ADP-ribosyltransferase 3|NAD+ ADP-ribosyltransferase 3|poly [ADP-ribose] polymerase 3|poly(ADP-ribose) synthetase-3|poly[ADP-ribose] synthase 3|poly[ADP-ribose] synthetase 3
Swissprots	Q9Y6F1 Q9UG81 Q96CG2 Q8NER9
Accessions	CAC07443 CAC07444 EAW65160 EAW65161 EAW65162 EAW65163 Q9Y6F1 AB208803 BAD92040 AF083068 AAD29855 AI088919 AL050034 CAB43246 AY126341 AAM95460 BC014260 AAH14260 BF375394 BG818516 BI554046 BU632340 CA309713 CA394313 JF432226 ADZ15443 Y16836 CAC79988 XM_005264779 XP_005264836 XM_011533257 XP_011531559 XM_011533258 XP_011531560 NM_001003931 NP_001003931 NM_005485 NP_005476 NM_001003935
Function	Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing. {ECO:0000269|PubMed:16924674}.
Subcellular Location	Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Core component of the centrosome. Preferentially localized to the daughter centriole throughout the cell cycle. According to PubMed:16924674, it is almost exclusively localized in the nucleus and appears in numerous small foci and a small number of larger foci whereas a centrosomal location has not been detected.
Tissue Specificity	Widely expressed; the highest levels are in the kidney, skeletal muscle, liver, heart and spleen; also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus.
Top Pathways	Base excision repair

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PARP3-Over-expression-Lysate - LY14996a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

PARP3 293T Cell Transient Overexpression Lysate(Denatured) - H00010039-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

PARP3 293 Cell Lysate - 401511 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

PARP3 Overexpression Lysate (Native) - NBL1-14116 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

PARP3 Overexpression Lysate (Native) - NBL1-14117 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

PARP-3 (h): 293 Lysate - sc-158814 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

PARP3 Over-expression Lysate Product - GWB-F3D186 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

PARP3 Over-expression Lysate Product - GWB-3E5BCE from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human PARP-3 / PARP3 Insect Cell Lysate (WB positive control) - 11190-H20BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

PARP3 Overexpression Lysate (Denatured) - H00010039-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

PARP3 Overexpression Lysate (Denatured) - H00010039-T03 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human PARP3 Knockdown Stable Cell Line - CSC-DC011320 from Creative biogene Category Cell Line Species Human

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