GALNT12
| Gene Symbol | GALNT12 |
|---|---|
| Entrez Gene | 79695 |
| Alt Symbol | CRCS1, GalNAc-T12 |
| Species | Human |
| Gene Type | protein-coding |
| Description | polypeptide N-acetylgalactosaminyltransferase 12 |
| Other Description | UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12|UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)|colorectal cancer, susceptibility to 1|polypeptide GalNAc transferase 12|pp-GaNTase 12|protein-UDP acetylgalactosaminyltransferase 12 |
| Swissprots | Q5TCF7 Q9H771 Q8IXK2 Q96CT9 Q8NG54 |
| Accessions | CAG32962 EAW58897 Q8IXK2 AB040673 BAD93346 AB078146 BAC07181 AJ132365 CAC80100 AJ505963 CAD44541 AK024865 BAB15027 BC013945 AAH13945 BC148409 AAI48410 BC148739 AAI48740 CB243715 XM_006717287 XP_006717350 XM_011519018 XP_011517320 XM_011519019 XP_011517321 XM_011519020 XP_011517322 NM_024642 NP_078918 |
| Function | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc- Muc5AC glycopeptide, but no detectable activity to mono-GalNAc- glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Tissue Specificity | Widely expressed at different levels of expression. Highly expressed in digestive organs such as small intestine, stomach, pancreas and colon. Expressed at intermediate level in testis, thyroid gland and spleen. Weakly expressed in whole brain, cerebral cortex, cerebellum, fetal brain, bone marrow, thymus, leukocytes, heart, skeletal muscle, liver, lung, esophagus, kidney, adrenal gland, mammary gland, uterus, placenta, ovary and prostate. {ECO:0000269|PubMed:12135769}. |
| Top Pathways | Mucin type O-Glycan biosynthesis |
GalNAc-T12 CRISPR/Cas9 KO Plasmid (h) - sc-413214 from Santa Cruz Biotechnology
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GalNAc-T12 HDR Plasmid (h) - sc-413214-HDR from Santa Cruz Biotechnology
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GalNAc-T12 Double Nickase Plasmid (h) - sc-413214-NIC from Santa Cruz Biotechnology
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GalNAc-T12 Double Nickase Plasmid (h2) - sc-413214-NIC-2 from Santa Cruz Biotechnology
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GalNAc-T12 CRISPR Activation Plasmid (h) - sc-413214-ACT from Santa Cruz Biotechnology
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GalNAc-T12 CRISPR Activation Plasmid (h2) - sc-413214-ACT-2 from Santa Cruz Biotechnology
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GalNAc-T12 Lentiviral Activation Particles (h) - sc-413214-LAC from Santa Cruz Biotechnology
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GalNAc-T12 Lentiviral Activation Particles (h2) - sc-413214-LAC-2 from Santa Cruz Biotechnology
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GalNAc-T12 siRNA (h) - sc-75088 from Santa Cruz Biotechnology
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GalNAc-T12 shRNA Plasmid (h) - sc-75088-SH from Santa Cruz Biotechnology
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GalNAc-T12 shRNA (h) Lentiviral Particles - sc-75088-V from Santa Cruz Biotechnology
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GALNT12 RNAi - H00079695-R01 from Novus Biologicals
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MISSION® esiRNA - EHU002091 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9104 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9104 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07497 from Sigma-Aldrich
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GALNT12 siRNA (Human) - CRJ2493 from Cohesion Biosciences
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GALNT12 - MBS8227123 from MyBioSource
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shRNA set against Human GALNT12 (NM_024642.4) - SHH298993 from Creative biogene
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Human GALNT12 siRNA - orb272994 from Biorbyt
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GALNT12 shRNA Plasmid (Human) - CHJ2493 from Cohesion Biosciences
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GALNT12 miRNA 3'UTR clone - MiUTR3H-11133 from Creative biogene
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