| Gene Symbol |
Parp1
|
| Entrez Gene |
100689463
|
| Alt Symbol |
ADPRT, ARTD1, PARP-1, Parp
|
| Species |
Hamster
|
| Gene Type |
protein-coding
|
| Description |
poly (ADP-ribose) polymerase 1
|
| Other Description |
ADP-ribosyltransferase diphtheria toxin-like 1|ADPRT 1|NAD(+) ADP-ribosyltransferase 1|Poly[ADP-ribose] synthase 1|poly ADP-ribose polymerase|poly [ADP-ribose] polymerase 1
|
| Swissprots |
Q9R152
|
| Accessions |
Q9R152 AF168781 AAD45817 JI880544 JI888153 JP043491 JP060255 NM_001246721 NP_001233650
|
| Function |
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production (By similarity). Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (By similarity).
|
| Subcellular Location |
Nucleus. Nucleus, nucleolus {ECO:0000250}. Note=Localizes at sites of DNA damage. {ECO:0000250}.
|
| Top Pathways |
Base excision repair
|