| Gene Symbol |
IKZF1
|
| Entrez Gene |
395974
|
| Alt Symbol |
IKAROS, ZNFN1A1
|
| Species |
Chicken
|
| Gene Type |
protein-coding
|
| Description |
IKAROS family zinc finger 1 (Ikaros)
|
| Other Description |
DNA-binding protein Ikaros|Ikaros transcription factor|ikaros family zinc finger protein 1|zinc finger protein, subfamily 1A, 1 (Ikaros)
|
| Swissprots |
O42410
|
| Accessions |
O42410 Y11833 CAA72531 NM_205088 NP_990419
|
| Function |
Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Functions in the specification and the maturation of the T-lymphocyte. Also interacts with a critical control element in the TDT (terminal deoxynucleotidyltransferase) promoter as well as with the promoters for other genes expressed during early stages of B- and T-cell development. Function is isoform-specific and is modulated by dominant-negative inactive isoforms (By similarity). {ECO:0000250|UniProtKB:Q03267, ECO:0000250|UniProtKB:Q13422}.
|
| Subcellular Location |
Nucleus {ECO:0000250|UniProtKB:Q13422}.
|
| Tissue Specificity |
Expressed in embryonic hematopoietic organs such as the bursa of Fabricius, thymus and spleen. In the adult, expressed in spleen, thymus, bursa and peripheral blood leukocytes. {ECO:0000269|PubMed:9295018}.
|