CSF1

Gene Symbol CSF1
Entrez Gene 1435
Alt Symbol CSF-1, MCSF
Species Human
Gene Type protein-coding
Description colony stimulating factor 1 (macrophage)
Other Description lanimostim|macrophage colony-stimulating factor 1
Swissprots Q9UQR8 Q5VVF3 Q14806 Q14086 A8K6J5 Q13130 Q5VVF4 P09603
Accessions AAB59527 CAA29479 CAJ32234 CAJ32235 CAJ32236 CBX54357 CBX55878 CBX55879 CBX55880 CCA65433 CCA65434 CCA65435 EAW56416 EAW56417 EAW56418 EAW56419 EAW56420 EAW56421 P09603 AB208952 BAD92189 AI758702 AK291660 BAF84349 AK300401 BAG62132 AK311440 BC021117 AAH21117 DA414355 DB287787 JF803735 AEF12310 M27087 AAA59573 M37435 AAA52117 M64592 AAA59572 M76453 AAA52120 U22386 AAA64849 X05825 CAA29265 NM_000757 NP_000748 NM_172210 NP_757349 NM_172211 NP_757350 NM_172212 NP_757351
Function Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. {ECO:0000269|PubMed:16337366, ECO:0000269|PubMed:19934330, ECO:0000269|PubMed:20504948, ECO:0000269|PubMed:20829061}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:1531650, ECO:0000269|PubMed:3264877}; Single-pass type I membrane protein {ECO:0000269|PubMed:1531650, ECO:0000269|PubMed:3264877}.
Top Pathways Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Osteoclast differentiation, Rheumatoid arthritis, PI3K-Akt signaling pathway

M-CSF (D-4) - sc-365779 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
M-CSF (D-4): sc-365779. Western blot analysis of human recombinant M-CSF.

M-CSF (N-16) - sc-1324 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
M-CSF (N-16): sc-1324. Western blot analysis of mouse recombinant M-CSF (A,B).

M-CSF (H-300) - sc-13103 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-MCSF antibody - ab9693 from Abcam

Prices $390.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab9693 staining MCSF in human cervical squamous cell carcinoma section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections). Tissue underwent heat mediated antigen retrieval in sodium citrate buffer (pH 6.0). The primary antibody was used at 5 ug/ml and incubated with sample at 4°C overnight. A HRP-labeled polymer detection system was used with a DAB chromogen.

Anti-MCSF antibody - ab99178 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MCSF antibody (ab99178) at 1 µg/mlLane 1 : Bone Marrow (Human) Tissue Lysate - adult normal tissue Lane 2 : Spleen (Human) Tissue Lysate - adult normal tissue (ab29699)Lane 3 : Thymus (Human) Tissue Lysate - adult normal tissue (ab30146)Lane 4 : Tonsil (Human) Tissue LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-MCSF antibody - ab66236 from Abcam

Prices $379.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
All lanes : Anti-MCSF antibody (ab66236) at 1 µg/mlLane 1 : MCSF transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 50 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Anti-MCSF antibody - ab99109 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-MCSF antibody (ab99109) at 1 µg/ml + COLO205 cell lysate at 10 µg

Anti-MCSF antibody - ab99110 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-MCSF antibody (ab99110) at 1 µg/ml + COLO205 cell lysate at 10 µg

Anti-MCSF antibody - ab93335 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-MCSF antibody (ab93335) at 1/100 dilution + NCI-H460 cell line lysates at 35 µg

Anti-MCSF antibody [116] - ab18676 from Abcam

Prices $370.00
Sizes 250 µg
Host Mouse
Clonality Monoclonal
Clone 116

Anti-MCSF antibody [21] - ab18645 from Abcam

Prices $376.00
Sizes 250 µg
Host Mouse
Clonality Monoclonal
Clone 21
Standard curve for MCSF (Analyte: ab62015); dilution range 1pg/ml to 1µg/ml using Capture Antibody Mouse monoclonal [21] to MCSF (ab18645) at 1µg/ml and Detector Antibody Rabbit polyclonal to MCSF (ab9693) at 0.1µg/ml.

Anti-MCSF antibody [692] - ab18640 from Abcam

Prices $370.00
Sizes 250 µg
Host Mouse
Clonality Monoclonal
Clone 692

Anti-MCSF antibody (Biotin) - ab84262 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-MCSF antibody [EP1179Y] - ab52864 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1179Y
ab52864 at 1/50 dilution stainng MCSF in human tonsil by Immunohistochemistry, Paraffin embedded tissue.

Anti-MCSF antibody [MM0466-3V17] - ab89571 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MM0466-3V17

Anti-CSF1 / MCSF Antibody (aa33-204) - LS-C314376 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of recombinant CSF1 / MCSF.

Anti-CSF1 / MCSF Antibody (aa223-496, clone 1F8) - LS-C340038 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 1F8
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CSF1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CSF1.

Anti-CSF1 / MCSF Antibody - LS-C104811 from LifeSpan Bioscience

Host Goat
Clonality Polyclonal
Western Blot (non-reducing) of CSF1 / M-CSF antibody LS-C104811

Anti-CSF1 / MCSF Antibody (aa223-496, clone 1D10) - LS-C340007 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 1D10
IHC of paraffin-embedded Carcinoma of Human liver tissue using anti-CSF1 mouse monoclonal antibody. (heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-CSF1 / MCSF Antibody (clone 1A9) - LS-C196978 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 1A9
Western Blot analysis of CSF1 expression in transfected 293T cell line by CSF1 monoclonal antibody (M01), clone 1A9.Lane 1: CSF1 transfected lysate(60.1 KDa).Lane 2: Non-transfected lysate.

Anti-CSF1 / MCSF Antibody (Biotin) - LS-C104655 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Sandwich ELISA of CSF1 / M-CSF antibody LS-C104655

Anti-CSF1 / MCSF Antibody (aa223-496, clone 2D6) - LS-C340010 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 2D6
IHC of paraffin-embedded Human tonsil using anti-CSF1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-CSF1 / MCSF Antibody (clone 2D10) IHC-plus™ - LS-B4135 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 2D10
Anti-CSF1 / MCSF antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4135 dilution 1:200.

Anti-CSF1 / MCSF Antibody (aa223-496, clone 8E1) - LS-C340011 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 8E1
IHC of paraffin-embedded Human Kidney tissue using anti-CSF1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-CSF1 / MCSF Antibody - LS-C104656 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
IHC of CSF1 / M-CSF antibody LS-C104656
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