| Gene Symbol |
ATP2A2
|
| Entrez Gene |
396446
|
| Alt Symbol |
SERCA2
|
| Species |
Chicken
|
| Gene Type |
protein-coding
|
| Description |
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
|
| Other Description |
SR Ca(2+)-ATPase 2|calcium pump 2|calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform|endoplasmic reticulum class 1/2 Ca(2+) ATPase|sarcoplasmic/endoplasmic reticulum calcium ATPase 2
|
| Swissprots |
Q03669
|
| Accessions |
Q03669 BU144998 BU446345 CN236570 M66385 AAA49066 NM_001271973 NP_001258902 NM_001271974 NP_001258903 NR_073529
|
| Function |
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Only isoform 2 is detected in heart, while both isoforms are expressed in brain, with isoform 2 being predominant.
|
| Top Pathways |
Calcium signaling pathway
|