| Gene Symbol | Rnps1 |
|---|---|
| Entrez Gene | 19826 |
| Alt Symbol | - |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | ribonucleic acid binding protein S1 |
| Other Description | RNA-binding protein with serine-rich domain 1 |
| Swissprots | Q922H8 Q3TMJ1 Q99M28 |
| Accessions | EDL22315 EDL22316 Q99M28 AK011475 AK143213 AK146443 BAE27176 AK151150 BAE30156 AK164151 AK165905 BAE38451 AK178555 AK179550 AK181984 AK182154 AK206201 AK211825 AK213636 AK219218 BB868062 BC002061 AAH02061 BC008089 AAH08089 BX526195 BY013195 CJ058744 X70067 CAA49672 XM_006523921 XP_006523984 NM_001080127 NP_001073596 NM_001080128 NP_001073597 NM_009070 NP_033096 |
| Function | Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in d |
| Subcellular Location | Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Nucleocytoplasmic shuttling protein. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles (By similarity). {ECO:0000250}. |
| Top Pathways | RNA transport, mRNA surveillance pathway |
RNPS1 CRISPR/Cas9 KO Plasmid (m) - sc-422692 from Santa Cruz Biotechnology
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RNPS1 HDR Plasmid (m) - sc-422692-HDR from Santa Cruz Biotechnology
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RNPS1 Double Nickase Plasmid (m) - sc-422692-NIC from Santa Cruz Biotechnology
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RNPS1 Double Nickase Plasmid (m2) - sc-422692-NIC-2 from Santa Cruz Biotechnology
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RNPS1 CRISPR Activation Plasmid (m) - sc-422692-ACT from Santa Cruz Biotechnology
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RNPS1 CRISPR Activation Plasmid (m2) - sc-422692-ACT-2 from Santa Cruz Biotechnology
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RNPS1 Lentiviral Activation Particles (m) - sc-422692-LAC from Santa Cruz Biotechnology
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RNPS1 Lentiviral Activation Particles (m2) - sc-422692-LAC-2 from Santa Cruz Biotechnology
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RNPS1 siRNA (m) - sc-38310 from Santa Cruz Biotechnology
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RNPS1 shRNA Plasmid (m) - sc-38310-SH from Santa Cruz Biotechnology
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RNPS1 shRNA (m) Lentiviral Particles - sc-38310-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU095551 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN40385 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND40385 from Sigma-Aldrich
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RNPS1 siRNA (Mouse) - CRM3498 from Cohesion Biosciences
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RNPS1 - MBS8219123 from MyBioSource
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shRNA set against Mouse RNPS1 (NM_009070.2) - SHH397556 from Creative biogene
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shRNA set against Mouse Rnps1(NM_009070.2) - SHR188784 from Creative biogene
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shRNA set against Mouse Rnps1(NM_001080128.1) - SHR188786 from Creative biogene
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shRNA set against Mouse Rnps1(NM_009070.2) - SHR188904 from Creative biogene
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shRNA set against Mouse Rnps1(NM_001080127.1) - SHR188934 from Creative biogene
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RNPS1 CRISPR/Cas9 KO Plasmid (m2) - sc-422692-KO-2 from Santa Cruz Biotechnology
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RNPS1 HDR Plasmid (m2) - sc-422692-HDR-2 from Santa Cruz Biotechnology
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Mouse RNPS1 siRNA - orb282974 from Biorbyt
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RNPS1 shRNA Plasmid (Mouse) - CHM3498 from Cohesion Biosciences
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