| Gene Symbol | IL6 |
|---|---|
| Entrez Gene | 403985 |
| Alt Symbol | IL-6 |
| Species | Dog |
| Gene Type | protein-coding |
| Description | interleukin 6 (interferon, beta 2) |
| Other Description | interleukin-6 |
| Swissprots | Q9MYZ7 P41323 |
| Accessions | AEJ54587 AEJ54588 P41323 AF275796 AAF86275 AF328929 AAL26923 AF333119 AAK01439 AF349534 U12234 AAA83030 Z70045 NM_001003301 NP_001003301 |
| Function | Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation (By similarity). {ECO:0000250}. |
| Subcellular Location | Secreted. |
| Top Pathways | Tuberculosis, Non-alcoholic fatty liver disease (NAFLD), Inflammatory bowel disease (IBD), Herpes simplex infection, Legionellosis |